摘要
目的:探讨应用微生态制剂治疗小儿腹泻的临床效果。方法:选取2022年1—12月合肥市第一人民医院收治的腹泻患儿84例为观察对象,根据随机数字表法分为对照组与观察组,各42例。对照组予以思密达治疗,观察组予以思密达联合微生态制剂治疗。比较两组患儿腹泻情况、肠道菌群、炎性因子水平、细胞免疫功能、临床疗效及不良反应发生率。结果:观察组腹泻次数少于对照组,止泻时间短于对照组,差异有统计学意义(P=0.000)。用药后,两组患儿乳酸杆菌属、肠球菌属含量均升高,酵母样真菌均降低,差异有统计学意义(P<0.05);观察组患儿乳酸杆菌属、肠球菌属含量高于对照组,酵母样真菌含量低于对照组,差异有统计学意义(P=0.000)。用药后,两组患儿白细胞介素-4、白细胞介素-6、C反应蛋白水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。用药后,两组患儿CD3+、CD4+、CD4+/CD8+水平均升高,CD8+水平均降低,差异有统计学意义(P<0.05);观察组CD3+、CD4+及CD4+/CD8+水平高于对照组,CD8+水平低于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P=0.048)。两组不良发生率比较,差异无统计学意义(P>0.05)。结论:小儿腹泻应用微生态制剂治疗的效果显著,可改善患儿的腹泻情况与肠道菌群,降低炎性因子水平,提高细胞免疫功能。
Objective:To explore the clinical effect of applying microecological preparations in the treatment of pediatric diarrhea.Methods:Eighty-four cases of children with diarrhea admitted to the Zunyi First People's Hospital from January to December 2022 were selected as observation subjects and divided into control group and observation group according to the random number table method,with forty-two cases each.The control group was treated with Smecta,and the observation group was treated with Smecta combined with microecological preparations.The diarrhea,intestinal flora,inflammatory factor level,cellular immune function,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results:The frequency of diarrhea in the observation group was less than that in the control group,and the time to stop diarrhea was shorter than that in the control group,and the difference was statistically significant(P=0.000).After medication,the content of Lactobacillus spp.and Enterococcus spp.increased and yeast-like fungi decreased in children of both groups,and the difference was statistically significant(P<0.05).In the observation group,the content of Lactobacillus spp.and Enterococcus spp.was higher than that in the control group,and the content of yeast-like fungi was lower than that in the control group,and the difference was statistically significant(P=0.000).After medication,the levels of interleukin-4,interleukin-6 and C-reactive protein were lower in both groups,and the difference was statistically significant(P<0.05).After medication,CD3+,CD4+,CD4+/CD8+levels increased and CD8+levels decreased in both groups of children,and the difference was statistically significant(P<0.05).The CD3+,CD4+and CD4+/CD8+levels in the observation group were higher than those in the control group,and the CD8+levels were lower than those in the control group,with statistically significant differences(P<0.05).The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.048).The difference was not statistically significant when comparing the incidence of adverse events in the two groups(P>0.05).Conclusion:The application of microecological preparations for pediatric diarrhea is effective in improving the diarrhea and intestinal flora of children,reducing the level of inflammatory factors,and improving cellular immune function.
作者
刘庆
Liu Qing(Zunyi First People's Hospital(Third Affiliated Hospital of Zunyi Medical University),Zunyi 563000,Guizhou Province,China)
出处
《中外医药研究》
2023年第1期27-29,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
小儿腹泻
微生态制剂
肠道菌群
炎性因子
细胞免疫功能
Pediatric diarrhea
Microecological preparations
Intestinal flora
Inflammatory factors
Cellular immune function
