摘要
目的评估老年共病患者的衰弱状态,探讨影响衰弱发生的相关危险因素。方法横断面研究,收集2019年4月至2020年12月在北京市万寿路地区年龄≥65岁的共病患者746例,最终纳入共病患者617例,年龄(85.6±4.8)岁,女性358例(58.0%);617例共病患者经FRAIL量表评分纳入衰弱组156例(25.3%)、非衰弱组461例(74.7%)。收集人口学资料、身体共病等信息,进行单因素和多因素Logistic回归分析,探讨衰弱发生的影响因素。结果617例共病患者常见的慢性病发病情况由高至低分别为高血压(497例,80.6%)、冠心病(375例,60.8%)、骨质疏松(357例,57.9%)、骨关节炎(281例,45.5%)、2型糖尿病(211例,34.2%)、卒中和(或)短暂性脑缺血发作(193例,31.3%)、慢性肺病(144例,23.3%)、肿瘤(133例,21.6%)、慢性肾病(92例,14.9%)、心力衰竭(58例,9.4%)。单因素分析结果显示,年龄、2型糖尿病、冠心病、心力衰竭、慢性肺病、卒中和(或)短暂性脑缺血发作、肿瘤、骨关节炎是衰弱发生的影响因素(均P<0.05)。多因素Logistic回归分析结果显示,年龄、2型糖尿病、心力衰竭、慢性肺病、肿瘤、骨关节炎是衰弱的危险因素(OR值分别为1.076、1.806、3.275、3.371、1.640、2.227,均P<0.05)。结论高龄、2型糖尿病、心力衰竭、慢性肺病、肿瘤、骨关节炎与老年共病患者衰弱的发生风险相关,应积极有效预防和干预衰弱发生的相关危险因素,减少不良结局的发生。
Objective To investigate frailty in older patients with comorbidities and explore related risk factors.Methods A cross-sectional study was conducted with an enrollment of 746 patients aged 65 years or older with comorbidities in the Wanshoulu Road area of Beijing from April 2019 to December 2020.A total of 617 patients with comorbidities were finally included,aged(85.6±4.8)years,including 358 women(58.0%);According to the FRAIL scale,617 patients with comorbidities were divided into a frail group(156 cases,25.3%)and a non-frail group(461 cases,74.7%).Demographic data and information on comorbidities were collected.Univariate and multivariate Logistic regression analyses of risk factors were conducted.Results Among 617 patients with comorbidities,the common chronic diseases in descending order were hypertension(497 cases,80.6%),coronary heart disease(375 cases,60.8%),osteoporosis(357 cases,57.9%),osteoarthritis(281 cases,45.5%),type 2 diabetes(211 cases,34.2%),stroke and/or transient ischemic attack(193 cases,31.3%),chronic lung disease(144 cases,23.3%),tumor(133 cases,21.6%),chronic kidney disease(92 cases,14.9%),and heart failure(58 cases,9.4%).Univariate logistic regression analysis showed that age,type 2 diabetes,coronary heart disease,heart failure,chronic lung disease,stroke/transient ischemic attack,cancer and osteoarthritis were influencing factors for frailty(P<0.05).Multivariate logistic regression analysis showed that age,type 2 diabetes,heart failure,chronic lung disease,cancer and osteoarthritis were risk factors for frailty(OR=1.076,1.806,3.275,3.371,1.640,2.227,all P<0.05).Conclusions Old age,type 2 diabetes,heart failure,chronic lung disease,tumor and osteoarthritis are closely related to frailty in elderly patients with comorbidities.Proactive and effective prevention and intervention should be instituted to target risk factors for frailty to reduce the occurrence of adverse outcomes.
作者
洛佳坤
刘睿涵
刘昱彤
孙沙沙
杨明艳
于焱
管博
黄鑫
范利
曹剑
Luo Jiakun;Liu Ruihan;Liu Yutong;Sun Shasha;Yang Mingyan;Yu Yan;Guan Bo;Huang Xin;Fan Li;Cao Jian(Department of Cardiology,the Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China;Chinese PLA Medical School,Beijing 100853,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2023年第5期493-497,共5页
Chinese Journal of Geriatrics
基金
军队保健课题(21BJZ26)
国家老年疾病临床医学研究中心开放课题(NCRCG-PLAGH-2022004)。
关键词
共病
衰弱
影响因素
Comorbidity
Frailty
Risk factor
