摘要
目的:研究替加氟温度敏感性脂质体在家兔体内的动力学特点。方法:家兔静注替加氟温度敏感性脂质体,用微波电疗仪对肝脏局部加热至(42±0.1)℃,测定血中药物浓度变化,观察其体内动力学特点。结果:替加氟温度敏感性脂质体肝脏局部加热后,促进了药物在肝脏局部的释放,改变了其动力学特性,提高了替加氟温度敏感性脂质体的靶向性。结论:替加氟温度敏感性脂质体配合肝脏局部加热可提高其靶向性。
Objective: To study the pharmacokinetics of fluoroful temperature-sensitive liposomes in rabbits. Methods: Fluoroful temperature-sensitive liposomes were intravenously administered into rabbits. Livers were heated to (42±0.1)℃ by microwave, blood concentrations of fluoroful were determined, the pharmacokinetics parameters of it were calculated. Results: After being heated, the drug releasing of fluoroful temperature-sensitive liposomes was accelerated, and the drug were controlled to be released into liver. Conclusion: Fluoroful temperature-sensitive liposomes can be controlled to release specifically into livers by heating the organs.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2002年第11期1227-1229,共3页
Academic Journal of Second Military Medical University
