摘要
溃疡性结肠炎以加重和缓解交替出现为特点,确定一种监测方法预测炎症的活动性尤为重要。粪便钙卫蛋白临床上应用较广泛,在几种粪便生物标志物中,粪便钙卫蛋白在预测静止期肠炎黏膜愈合更准确,生物标志物监测相较于结肠镜具有无创、操作简便、患者易接受等优点;能直接反映肠管炎症反应中粒细胞的状态,能让活动期的溃疡性结肠炎患者避免不必要的侵入性手术,在疾病情况的评估、临床管理、随访等方面有望形成新的评分和管理策略。
Ulcerative colitis is characterized by exacerbation and remission alternately.It is particularly important to determine a monitoring method to predict the activity of inflammation.Fecal calprotectin is widely used clinically.Among several fecal biomarkers,fecal calprotectin is more accurate in predicting mucosal healing in quiescent enteritis.Compared with colonoscopy,biomarker monitoring has the advantages of non-invasiveness,simple operation,and easy acceptance by patients,which can directly reflect the state of neutrophils in the intestinal inflammatory response,and can avoid unnecessary invasive surgery for patients with active ulcerative colitis.It is expected to form a new score and management strategy for the convenience of disease assessment,clinical management,and follow-up.
作者
张富
林晓东
吴光耀
李松湖
黄玫婷
黄亮
ZHANG Fu;LIN Xiaodong;WU Guangyao;LI Songhu;HUANG Meiting;HUANG Liang(Department of Gastroenterology,Dongguan Kanghua Hospital,Dongguan,Guangdong Province,523000 China)
出处
《中外医疗》
2023年第7期189-193,共5页
China & Foreign Medical Treatment
