摘要
代谢性炎症是一种慢性低度炎性状态,常由代谢功能异常、免疫系统紊乱及组织内代谢产物异常蓄积引发,参与包括肥胖症、2型糖尿病、高脂血症、动脉粥样硬化在内多种疾病的病理生理过程。研究表明代谢性炎症是心血管事件发生的高危风险因素之一,可能与冠状动脉微血管疾病的发生和发展有关。本文对代谢性炎症相关基因与冠状动脉微血管疾病患病关系做一综述,旨在为冠状动脉微血管疾病的早期筛查及预防提供新方向。
Metabolic inflammation is a chronic low-grade inflammatory state,often caused by abnormal metabolic function,immune system disorders and abnormal accumulation of metabolites in tissues.It is involved in the pathophysiological processes of many diseases,including obesity,type 2 diabetes,hyperlipidemia and atherosclerosis.The studies have shown that metabolic inflammation is one of the high risk factors for cardiovascular events and may be related to the occurrence and development of coronary microvascular disease.This article reviews the relationship between the genes related to metabolic inflammation and coronary microvascular disease to provide a new direction for the early screening and prevention of coronary microvascular disease.
作者
郭星辰
高万昊
李牧蔚
GUO Xing-chen;GAO Wan-hao;LI Mu-wei(Department of Cardiology,People’s Hospital of Zhengzhou University,Zhengzhou 450003,China)
出处
《中国心血管病研究》
CAS
2023年第5期458-463,共6页
Chinese Journal of Cardiovascular Research
基金
河南省科学技术厅2020年科学发展计划(202300410465)。
关键词
代谢性炎症
冠状动脉微血管疾病
微血管功能障碍
基因调控
作用机制
Metabolic inflammation
Coronary microvascular disease
Microvascular dysfunction
Regulation of gene expression
Mechanism of action
