摘要
目的探讨C反应蛋白/白蛋白比值(CRP/ALB,CAR)、中性粒细胞/淋巴细胞比值(NE/LY,NLR)在预测绝经后女性冠状动脉病变程度中的临床价值。方法纳入2017年1月至2022年12月于合肥市第二人民医院心内科住院并行冠状动脉造影的绝经女性患者593例进行回顾性分析。根据年龄分为中年绝经组(n=332)和老年绝经组(n=261);根据冠状动脉造影Gensini评分(GS),分为对照组(n=210)、轻度组(n=235)及严重组(n=148)。比较各组CAR、NLR有无差异,采用Pearson分析检验CAR、NLR与GS的相关性,采用logistic回归筛选冠状动脉严重病变及不同年龄段绝经女性冠心病的独立影响因素,采用ROC曲线分析CAR、NLR及二者联合对冠状动脉多支病变的预测价值。结果各年龄段绝经后女性中,冠心病组CAR、NLR均高于对照组,冠状动脉严重病变组CAR、NLR高于轻度病变组(P<0.01);Pearson相关分析表明CAR、NLR与GS呈正相关(r_(CAR)=0.406,r_(NLR)=0.390,P<0.01);多因素了logistic回归分析结果显示,CAR及NLR为冠状动脉严重病变的独立危险因素(P<0.01);ROC分析显示,CAR、NLR及二者联合均对冠状动脉多支病变有预测价值,且二者联合时曲线下面积(AUC)更大,预测效能高于单个指标(P<0.01)。结论CAR、NLR可作为绝经后女性冠状动脉病变程度的独立预测因素,可用于冠心病的诊断及病情评估。
Objective To investigate the clinical value of C-reactive protein/albumin ratio(CRP/ALB,CAR)and neutrophil/lymphocyte ratio(NE/LY,NLR)in predicting the extent of coronary artery lesions in postmenopausal women.Methods 593 cases of menopausal female patients who were hospitalized in the Department of Cardiology and underwent coronary angiography in the Second People’s Hospital of Hefei from January 2017 to December 2022 were included for retrospective analysis.According to the age,they were divided into middle-aged menopause group(n=332)and older menopause group(n=261);according to the coronary angiography Gensini score(GS),they were divided into control group(n=210),mild group(n=235)and severe group(n=148).The differences in CAR and NLR among the groups were compared;Pearson analysis was used to test the correlation between CAR,NLR and GS;logistic regression was used to screen the independent influencing factors of the severe extent of coronary lesions and the occurrence of coronary artery disease at different aged period and ROC curve was used to analyze the predictive value of CAR,NLR and the combination of both for multiple lesions in coronary arteries.Results Among the postmenopausal women of all ages,CAR and NLR were higher in the coronary artery disease group than in the control group;CAR and NLR were higher in the severe group than in the mild group(P<0.01).Pearson correlation analysis showed that CAR and NLR were both positively correlated with GS(rCAR=0.406,rNLR=0.390,P<0.01).Multifactorial logistic regression analysis showed that both CAR and NLR were the independent risk factors for severe coronary artery lesions(P<0.01).ROC analysis showed that CAR,NLR and the combination of both had the predictive value for coronary multiple lesions;the area under the curve(AUC)was greater when the two were combined,and the predictive efficacy was higher than that of individual indicators(P<0.01).Conclusion CAR and NLR could be used as the independent predictors of the degree of coronary artery disease in postmenopausal women and for the diagnosis and condition assessment of coronary artery disease.
作者
夏梦远
徐涛良
倪润泽
张静
高玉
冯俊
XIA Meng-yuan;XU Tao-liang;NI Run-ze;ZHANG Jing;GAO Yu;FENG Jun(Department of Cardiology,Hefei Second People’s Hospital,Hefei Hospital affiliated to Anhui Medical University,Hefei 230000,China;The Fifth Clinical School of Anhui Medical University)
出处
《中国心血管病研究》
CAS
2023年第5期390-396,共7页
Chinese Journal of Cardiovascular Research
基金
2021年安徽省重点研究与开发计划(第一批)(202104j07020058)。
