摘要
目的 分析1990—2019年中国先天性出生缺陷的疾病负担变化趋势。方法 利用2019全球疾病负担数据库(GBD 2019),分析先天性出生缺陷疾病的发病率、死亡率、伤残调整寿命年(DALY)及其年龄标化率和平均年度百分比变化率(AAPC),分析1990—2019年中国先天性出生缺陷疾病负担变化情况,并与全球数据进行比较。结果 2019年中国先天性出生缺陷年龄标化发病率为147.41/10万,年龄标化死亡率为4.62/10万,年龄标化DALY率为480.95/10万。与1990年相比,2019年中国先天性出生缺陷年龄标化发病率、年龄标化死亡率、年龄标化DALY率分别上升12.08%与下降70.38%、66.82%。近年来,尽管中国先天性出生缺陷疾病年龄标化发病率呈上升趋势,但疾病负担大致呈下降趋势,且低于全球水平。这与较早的疾病干预及治疗使标化死亡率降低密切相关。结论 1990—2019年中国先天性出生缺陷患儿的年龄标化死亡率呈下降趋势,疾病负担从略高于全球到低于全球水平,但年龄标化发病率显著升高。
Objective To analyze the trend of disease burden changes in congenital birth defects in China from 1990 to 2019.Methods Using the global burden of disease study 2019(GBD 2019),we analyzed the morbidity,mortality,and disability-adjusted life years(DALYs)of congenital birth defect diseases and their corresponding age-standardized rates and average annual percentage change(AAPC)to analyze the changes in the disease burden of congenital birth defects in China and compared them with global data from 1990 to 2019.Results In 2019,the age-standardized incidence,mortality,and DALY in China were 147.41/100000,4.62/100000,480.95/100000,respectively.Compared with 1990,the age-standardized incidence rate,age-standardized mortality rate,and age-standardized DALY rate increased by 12.08%and decreased by 70.38%and 66.82%,respectively.In recent years,although the age-standardized incidence of congenital birth defect disease in China is on the rise and higher than the global level,the disease burden is roughly on the decline and lower than the global level,which is closely related to earlier intervention and treatment of the disease resulting in a lower standardized mortality rate.Conclusion The age-standardized mortality rate of children with congenital birth defects in China showed a decreasing trend from 1990 to 2019,and the burden of disease ranged from slightly higher than global to lower than global levels,but the age-standardized incidence rate was significantly higher,but the age-specific incidence rate has increased significantly.
作者
冷雪
肖文艳
郑娟
王凤英
LENG Xue;XIAO Wenyan;ZHENG Juan;WANG Fengying(The Second Department of Obstetrics,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,P.R.China;The Second Department of Intensive Care Unit,the Second Affiliated Hospital of Anhui Medical University,Hefei 230601,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2023年第4期386-390,共5页
Chinese Journal of Evidence-based Medicine
基金
安徽省卫健委科研项目(编号:AHWJ2022b085)
安徽省转化医学项目(编号:2022zhyx-C46)。
