摘要
目的观察妊娠期亚临床甲状腺功能减退(SCH)孕妇实施早期治疗的效果及对妊娠结局的影响。方法152例妊娠期SCH孕妇,按照是否接受早期治疗分为观察组(105例)和对照组(47例)。观察组给予早期治疗,对照组未接受早期治疗,仅给予常规护理措施。对比两组不良妊娠结局发生情况、甲状腺自身抗体[甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)]、甲状腺功能[血清三碘甲状腺原氨酸(T3)、促甲状腺素(TSH)、游离甲状腺素(FT4)]。结果观察组不良妊娠结局发生率26.67%低于对照组的48.94%,差异有统计学意义(P<0.05)。分娩前1个月,观察组TgAb(36.46±5.03)U/ml、TPOAb(137.43±42.35)U/ml低于对照组的(58.47±7.36)、(296.46±40.23)U/ml,差异有统计学意义(P<0.05)。分娩前1个月,观察组TSH(2.83±0.87)mU/L低于对照组的(4.25±0.82)mU/L,T3(2.47±0.56)nmol/L、FT4(17.98±4.25)pmol/L高于对照组的(1.18±0.50)nmol/L、(14.27±3.10)pmol/L,差异有统计学意义(P<0.05)。结论早期治疗妊娠期SCH有利于孕妇甲状腺功能恢复,改善妊娠结局。
Objective To observe the effect of early treatment of subclinical hypothyroidism(SCH)during pregnancy and its influence on pregnancy outcome.Methods A total of 152 pregnant women with SCH were divided into observation group(105 cases)and control group(47 cases)according to whether they received early treatment.The observation group received early treatment,the control group did not receive early treatment,only given conventional nursing measures.Both groups were compared in terms of adverse pregnancy outcome,thyroid autoantibodies[thyroglobulin antibody(TgAb),thyroid peroxidase antibody(TPOAb)],thyroid function[serum triiodothyronine(T3),thyroid-stimulating hormone(TSH),free thyroxin(FT4)].Results The incidence of adverse pregnancy outcome in the observation group was 26.67%,which was lower than that of 48.94%in the control group,and the difference was statistically significant(P<0.05).1 month before delivery,TgAb of(36.46±5.03)U/ml and TPOAb of(137.43±42.35)U/ml in the observation group were lower than those of(58.47±7.36)and(296.46±40.23)U/ml in the control group,and the difference was statistically significant(P<0.05).1 month before delivery,TSH of(2.83±0.87)mU/L in the observation group was lower than that of(4.25±0.82)mU/L in the control group;T3 of(2.47±0.56)nmol/L and FT4 of(17.98±4.25)pmol/L in the observation group were higher than those of(1.18±0.50)nmol/L and(14.27±3.10)pmol/L in the control group;the differences were statistically significant(P<0.05).Conclusion Early treatment of SCH during pregnancy is beneficial to the recovery of thyroid function in pregnant women and improves pregnancy outcomes.
作者
范冬林
FAN Dong-lin(Maternal and Child Health Hospital of Fangshan District,Beijing 102488,China)
出处
《中国现代药物应用》
2023年第8期97-99,共3页
Chinese Journal of Modern Drug Application
