摘要
目的观察井穴刺络放血疗法辅助丙戊酸钠治疗痰阻清窍型癫痫的疗效及对血清Tau蛋白磷酸化(P-tau)、核转录因子-κBp50/65(NK-κB50/65)、白细胞介素-10(IL-10)含量的影响。方法将我院60例痰阻清窍型癫痫患者随机分为观察组与对照组各30例。观察组予井穴刺络放血疗法辅助丙戊酸钠治疗,对照组服用丙戊酸钠治疗。评定两组治疗后总有效率,记录两组治疗前后癫痫发作次数、持续时间,检测两组治疗前后P-tau、NK-κBp50、NK-κBp65、IL-10水平,记录30 s内δ、θ、α、β数量。结果治疗后,观察组总有效率高于对照组(P<0.05);两组患者癫痫发作次数、持续时间较治疗前显著下降(均P<0.05),且观察组癫痫发作次数、持续时间下降程度较对照组更显著(均P<0.05);治疗后,两组患者P-tau、NK-κBp50、NK-κBp65、IL-10含量较治疗前显著下降(均P<0.05),且观察组P-tau、NK-κBp50、NK-κBp65、IL-10含量下降程度较对照组更显著(均P<0.05);治疗后,两组患者30 s内δ、θ、α、β数量较治疗前显著下降(均P<0.05),且观察组30 s内δ、θ、α、β数量低于对照组(均P<0.05)。结论井穴刺络放血疗法辅助丙戊酸钠治疗痰阻清窍型癫痫的疗效显著,降低癫痫发作次数、持续时间,调节P-tau、NK-κBp50、NK-κBp65、IL-10表达,改善脑电活动。
Objective To observe the therapeutic effect of blood letting therapy at well points combined with sodium valproate in treatment of phlegm obstructing and clearing orifices type of epilepsy,and its effect on serum tau protein phosphorylation(P-tau)and nuclear transcription factor-kBp50/65(NK-kB50/65)and interleukin-10(IL-10)content.Methods Sixty patients with phlegm obstructing and clearing orifices type of epilepsy were randomly divided into observation group and control group with 30 cases each.Observation group was treated with well point pricking and bloodletting therapy and sodium valproate,while control group was treated with sodium valproate.Both groups were treated continuously for two courses of treatment.The total effective rate of the two groups after treatment were evaluated,the number and duration of seizures before and after treatment were recorded,and P-tau,NK-kBp50,NK-kBp65,IL-10 contents of the two groups before and after treatment were detected,within 30sδ、θ、α、βquantities were recorded.ResultssAfter treatment,the total effective rate of observation group was higher than control group(all P<0.05);the number and duration of epileptic seizures in both groups decreased significantly compared with before treatment(all P<0.05),and the decreases in observation group were more significantly than control group(all P<0.05);P-tau,NK-kBp50,NK-kBp65,IL-10 contents decreased significantly in both groups compared with before treatment(all P<0.05),and the decreases in observation group were more significantly than control group(all P<0.05);the numbers ofδ、θ、α、βwithin 30s decreased significantly in both groups compared with before treatment(all P<0.05),and were lower in observation group than control group(all P<0.05).Conclusion Acupuncture and bloodletting therapy at well points assisted with sodium valproate has a significant effect in treatment of phlegm obstructing and clearing orifices type of epilepsy by reducing the frequency and duration of seizures,regulating the expression of P-tau,NK-kBp50,NK-kBp65,IL-10 impressions,and improving the EEG activity.
作者
张涛
ZHANG Tao(Shijiazhuang Hospital of TCM,Shijiazhuang 050000)
出处
《湖北中医药大学学报》
2023年第2期102-105,共4页
Journal of Hubei University of Chinese Medicine
基金
河北中医药管理局科研计划项目(项目编号:2022170)。
关键词
癫痫
痰阻清窍型
疗效
TAU蛋白磷酸化
井穴刺络放血疗法
丙戊酸钠
Epilepsy
Phlegm obstructing and clearing orifices
Efficacy
Tau protein phosphorylation
Blood letting therapy at well points
Sodium valproate
