摘要
目的分析甲状腺乳头状癌组织中巨囊性病液体蛋白15(GCDFP15)、类肌钙蛋白(Calponin)的表达水平及临床意义。方法选取2014年1月至2017年5月于该院确诊并行手术切除的102例甲状腺乳头状癌患者作为研究对象,收集其癌组织(研究组)及相对应的癌旁正常组织(正常组)标本,采用免疫组织化学法检测两组GCDFP15、Calponin的表达情况,分析GCDFP15、Calponin表达与甲状腺乳头状癌患者临床病理特征的关系,采用单因素、多因素COX回归分析GCDFP15、Calponin表达与甲状腺乳头状癌预后的关系。结果研究组GCDFP15阳性表达率(64.71%)明显高于对照组(29.41%),研究组Calponin阳性表达率(39.22%)明显低于对照组(66.68%),差异均有统计学意义(P<0.05)。GCDFP15、Calponin表达在不同TNM分期、侵犯被膜、淋巴结转移的甲状腺乳头状癌患者之间差异有统计学意义(P<0.05)。GCDFP15、Calponin阳性与阴性患者对应5年生存率比较差异均有统计学意义(P<0.05)。单因素分析结果显示,甲状腺乳头状癌5年生存率与TNM分期、侵犯被膜、淋巴结转移、GCDFP15阳性及Calponin阴性表达有关(P<0.05)。多因素COX分析结果显示,TNM T 3~4期、淋巴结转移、侵犯被膜及GCDFP15阳性、Calponin阴性均为影响甲状腺乳头状癌病预后的独立危险因素(P<0.05)。结论甲状腺乳头状癌患者癌组织中GCDFP15、Calponin表达情况与甲状腺乳头状癌患者TNM分期、侵犯被膜、淋巴结转移有关,二者有望成为评估甲状腺乳头状癌患者预后的有效指标。
Objective To analyze the expression levels of gross cystic disease fluid protein-15(GCDFP-15)and Calponin in papillary thyroid carcinoma and their clinical significance.Methods From January 2014 to May 2017,102 patients with papillary thyroid carcinoma who were diagnosed and underwent surgical resection in this hospital were selected as research objects.Samples of their cancer tissues(study group)and corresponding adjacent normal tissues(normal group)were collected.Immunohistochemistry was used to detect the expressions of GCDFP15 and Calponin in the two groups.The relationship between the expressions of GCDFP15,Calponin and the clinicopathologic features of thyroid papillary carcinoma patients were analyzed.Univariate and multivariate COX regression analysis were used to explore the relationship between the expression of GCDFP15,Calponin and prognosis of the papillary thyroid carcinoma.Results The positive expression rate of GCDFP15 in the study group(64.71%)was significantly higher than that in the control group(29.41%),and the positive expression rate of Calponin in the study group(39.22%)was significantly lower than that in the control group(66.68%),with statistical significance(P<0.05).The expressions of GCDFP15 and Calponin in papillary thyroid carcinoma patients with different TNM stages,capsule invasion and lymph node metastasis were statistically significant(P<0.05).The 5-year survival rates of GCDFP15 and Calponin positive and negative patients were statistically significant(P<0.05).Univariate analysis showed that the 5-year survival rate of papillary thyroid carcinoma was associated with TNM stage,capsule invasion,lymph node metastasis,GCDFP15 positive and Calponin negative expression(P<0.05).Multivariate COX analysis showed that TNM stage T 3-4,lymph node metastasis,capsule invasion,positive GCDFP15 and negative Calponin were independent risk factors for the prognosis of papillary thyroid carcinoma(P<0.05).Conclusion The expressions of GCDFP15 and Calponin in papillary thyroid carcinoma tissues are related to TNM stage,capsule invasion and lymph node metastasis,which are expected to be effective indicators for evaluating the prognosis of patients with papillary thyroid cancer.
作者
毛玉
韩爱军
刘勋
杨建均
胡恒辉
罗阳
MAO Yu;HAN Aijun;LIU Xun;YANG Jianjun;HU Henghui;LUO Yang(Department of Pathology,Leshan People′s Hospital,Leshan,Sichuan 614000,China)
出处
《国际检验医学杂志》
CAS
2023年第9期1090-1094,共5页
International Journal of Laboratory Medicine
