摘要
非酒精性脂肪性肝病(NAFLD)是世界范围内慢性肝病的重要原因,其患病率的持续增高已对人体健康造成严重威胁。维生素D是一种抗纤维化、抗炎和胰岛素增敏分子,参与肠道-脂肪组织-肝轴内的免疫代谢途径。流行病学研究支持维生素D缺乏症与NAFLD有关,在动物实验及体外研究中发现,抑制核苷酸结合寡聚化结构域样受体蛋白3炎症小体和焦亡的激活可以延缓肝脏脂肪变性及纤维化。本研究综述细胞焦亡和维生素D在NAFLD发病中的研究进展,探讨三者的相互关联,为维生素D基于焦亡为靶点治疗NAFLD的可能性提供参考。
Non-alcoholic fatty liver disease(NAFLD)is an important cause of chronic liver disease worldwide,and the continuous increase in its prevalence has posed a serious threat to human health.Vitamin D is a molecule with anti-fibrotic,anti-inflammatory and insulin-sensitizing properties that has been shown to participate in immunometabolic pathways within the gut-adipose tissue-liver axis.Epidemiological studies support the association of vitamin D deficiency and NAFLD,and in animal experiments and in vitro studies,inhibiting NLRP3 activation of inflammasome and pyroptosis was found to delay liver steatosis and fibrosis.This review summarized the progress of research on pyroptosis and vitamin D in the pathogenesis of NAFLD to explore the correlation between the three and provide a reference for the possibility of targeting vitamin D to target the NAFLD disease.
作者
景洁
刘菊香
权金星
Jing Jie;Liu Juxiang;Quan Jinxing(The First Clinical Medical School,Lanzhou University,Lanzhou 730000,China;Department of Endocrinology,Gansu Provincial Hospital,Lanzhou 730000,China)
出处
《兰州大学学报（医学版）》
2023年第2期84-89,共6页
Journal of Lanzhou University（Medical Sciences）
基金
国家自然科学基金资助项目(81860091,81960160)
甘肃省自然科学基金资助项目(20JR5RA155)。
