摘要
阿尔茨海默病(Alzheimer's disease,AD)是最常见的神经退行性疾病,因大脑逐渐退化而引起记忆、日常功能减退和行为障碍问题,俗称“老年痴呆”。痴呆症患者有多种类型,阿尔茨海默病占比最大,目前尚无逆转其病程的特效药物。近年来,对这种疾病的发病机制及药物尤其是中药及复方治疗方面,逐步取得了实质性进展,利用动物与细胞模型,诸多研究学者已经从不同角度证实了人参药材提取物、有效部位、单体化合物及复方人参制剂治疗AD具有显著的疗效。就近年来国内外关于人参对AD的治疗新进展研究文献进行梳理归纳,为将其开发成治疗阿尔茨海默病和各种类型记忆障碍的健康产品提供参考和科学依据。
Alzheimer's disease(AD)is the most common neurodegenerative disease,which causes memory,daily function decline and behavior disorders due to the gradual degradation of the brain,commonly known as"senile dementia".There are many types of dementia patients,and AD accounts for the largest proportion.At present,there is no specific drug to reverse the course of the disease.In recent years,substantial progress has been made in the pathogenesis and drugs of this disease,especially in the treatment of traditional Chinese medicine and compound prescription.Using animal and cell models,many researchers have confirmed the effectiveness of Renshen(Ginseng Radix Et Rhizoma)extract from different angles.This paper combed and summarized the research literature on the new progress of Renshen(Ginseng Radix Et Rhizoma)in the treatment of AD at home and abroad in recent years,so as to provide reference and scientific basis for developing it into a healthy product for the treatment of senile dementia and various types of memory disorders.
作者
王超楠
赵大庆
严铭铭
王隶书
WANG Chaonan;ZHAO Daqing;Yan Mingming;WANG Lishu(Changchun University of Chinese Medicine,Changchun 130117,Jilin,China;Jilin Provincial Academy of Chinese Medicine Sciences,Changchun 130021,Jilin,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第3期116-122,共7页
Chinese Archives of Traditional Chinese Medicine
基金
国家重点研发计划项目(2017YFC1702100)
吉林省重点研发项目(20200404073YY)
吉林省医药健康产业专项(20191102014YY)。
关键词
阿尔茨海默病
人参
药理作用机制
研究进展
Alzheimer's disease
Renshen(Ginseng Radix Et Rhizoma)
pharmacological mechanism
research progress
