摘要
Hawanoids A–E(1–5), five highly cyclized diterpenoids were isolated from the deep-sea-derived fungus Paraconiothyrium hawaiiense FS482. Compounds 1 and 2 possessed an unprecedented tetracyclo[6.6.2.0^(2,7).0^(11,15)]cetane carbon skeleton while 3 and 4 possessed an unusual 11,14-macrocyclic ether moiety in phomactin family. Their structures including the stereo-chemistry were determined through spectroscopic analysis, X-ray diffractions and computational calculations. The plausible biosynthetic pathway was proposed based on the predicted biosynthetic gene cluster. All of the isolated compounds exhibited inhibitory activities against PAF-induced platelet aggregation. The molecular docking study was carried out understand the interaction between the PAF receptor and hawanoids with different skeletons.
基金
funded by National Natural Science Foundation of China (Nos. 41906106, 31272087)
the Natural Science Foundation of Guangdong Province, China (No. 2021A1515011416)
Guangdong Special Support Program (No. 2019TQ05Y375)
Guangdong Provincial Special Fund for Marine Economic Development Project (No. GDNRC [2021]054)。
