摘要
目的分析慢性阻塞性肺疾病(COPD)伴发静脉血栓栓塞症(VTE)患者同型半胱氨酸(Hcy)、载脂蛋白A/B(apoA/apoB)水平与甲状腺激素的关系。方法选择2020年6月-2022年6月医院53例COPD伴发VTE患者为观察组,另选取同期53例COPD患者为对照组。依据卡普里尼(Caprini)评分将观察组患者分为低危组、中危组、高危组;检测所有患者Hcy、apoA/apoB及甲状腺激素;分析COPD伴发VTE患者Hcy、apoA/apoB与甲状腺激素的关系。结果53例COPD伴发VTE患者低危14例(26.42%)、中危27例(50.94%)、高危12例(22.64%);观察组促甲状腺激素(TSH)、血清总甲状腺素(TT4)、总三碘甲状腺原氨酸(TT3)、血清游离甲状腺素(FT4)、血清游离三碘甲状腺原氨酸(FT3)、apoA/apoB水平低于对照组,Hcy水平高于对照组,差异有统计学意义(P均<0.05);高危组TSH、TT3、FT4、FT3、apoA/apoB最低,其次为中危组,低危组最高,高危组Hcy最高,其次中危组,低危组最低,差异有统计学意义(P均<0.05);经Pearson相关性检验发现,COPD伴发VTE患者TSH、TT3、FT4、FT3表达与Hcy呈负相关(r<0,P<0.05),与apoA/apoB呈正相关(r>0,P<0.05)。结论Hcy、apoA/apoB水平与COPD伴发VTE患者甲状腺激素密切相关。
Objective To analyze the relationship between the levels of homocysteine(Hcy),apolipoprotein A/B(apoA/apoB),and thyroid hormones in patients with chronic obstructive pulmonary disease(COPD)accompanied by venous thromboembolism(VTE).Methods From June 2020 to June 2022,53 patients with COPD accompanied by VTE in the hospital were selected as the observation group,and 53 patients with COPD in the same period were selected as the control group.The patients in the observation group were divided into a low-risk group,medium-risk group,and high-risk group according to the Caprini score.Hcy,apoA/apoB,and thyroid hormone were detected in all patients.To analyze the relationship between Hcy,apoA/apoB,and thyroid hormones in COPD patients with VTE.Results Among the 53 patients with COPD complicated with VTE,14 cases were low-risk(26.42%),27 cases were medium-risk(50.94%),and 12 cases were high-risk(22.64%).The levels of thyroid-stimulating hormone(TSH),total thyroxine(TT4),total triiodothyronine(TT3),free thyroxine(FT4),free triiodothyronine(FT3),apoA/apoB in the observation group were lower than those in the control group,and the level of Hcy was higher than that in the control group,with statistically significant differences(all P<0.05);TSH,TT3,FT4,FT3,apoA/apoB in the high-risk group were the lowest,followed by the medium risk group,the low-risk group was the highest;the high-risk group had the highest Hcy,followed by the medium risk group,and the low-risk group was the lowest,the difference was statistically significant(all P<0.05);Pearson correlation test found that the expression of TSH,TT3,FT4,FT3 was negatively correlated with Hcy in COPD patients with VTE(r<0,P<0.05),and positively correlated with apoA/apoB(r>0,P<0.05).Conclusion Hcy and apoA/apoB levels are closely related to thyroid hormones in COPD patients with VTE.
作者
韩京旭
赵雪锋
岳红云
HAN Jing-xu;ZHAO Xue-feng;YUE Hong-yun(Department of Respiratory Medicine,Shijiazhuang Municipal people′s Hospital,Shijiazhuang,Hebei 050000,China;Department of Infectious diseases,Shijiazhuang Municipal people′s Hospital,Shijiazhuang,Hebei 050000,China)
出处
《临床肺科杂志》
2023年第5期694-698,共5页
Journal of Clinical Pulmonary Medicine
基金
河北省医学科学研究重点课题项目(No.20191483)。
