摘要
目的研究艾地苯醌联合尼莫地平治疗脑梗死后血管性认知功能障碍(VCI)的疗效和安全性。方法105例脑梗死后VCI患者,随机分为观察组(53例)和对照组(52例)。对照组给予尼莫地平治疗,观察组给予艾地苯醌联合尼莫地平治疗。对比两组临床疗效和不良反应发生情况。结果观察组治疗总有效率90.57%明显高于对照组的73.08%,差异有统计学意义(P<0.05)。观察组不良反应发生率11.32%与对照组的9.62%对比,差异无统计学意义(P>0.05)。结论通过艾地苯醌联合尼莫地平对脑梗死后VCI患者进行治疗,能在确保安全的前提下提升临床疗效,值得推荐。
Objective To study the efficacy and safety study of idebenone combined with nimodipine in the treatment of vascular cognitive impairment(VCI)after cerebral infarction.Methods A total of 105 patients with VCI after cerebral infarction were randomly divided into observation group(53 cases)and control group(52 cases).The control group was treated with nimodipine,and the observation group was treated with idebenone and nimodipine.The clinical efficacy,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of 90.57%in the observation group was significantly higher than that of 73.08%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was 11.32%in the observation group,and 9.62%in the control group,and the difference was not statistically significant(P>0.05).Conclusion The treatment of VCI patients after cerebral infarction by idebenone combined with nimodipine can improve clinical efficacy while ensuring safety and is recommended.
作者
王瑾
赵荣华
卑红喆
张尊
WANG Jin;ZHAO Rong-hua;BEI Hong-zhe(Department of Orthopedics,Baogang Hospital of Inner Mongolia,Baotou 014010,China)
出处
《中国现代药物应用》
2023年第6期102-104,共3页
Chinese Journal of Modern Drug Application
