摘要
目的观察方氏头针联合口服盐酸多奈哌齐片治疗轻中度缺血性卒中后认知功能障碍的临床疗效。方法将66例轻中度缺血性卒中后认知功能障碍患者随机分为观察组(33例,脱落1例)和对照组(33例,脱落1例,剔除1例)。两组患者均予卒中后常规药物治疗及运动康复训练。对照组每晚睡前口服盐酸多奈哌齐片,观察组在对照组口服药物基础上予方氏头针针刺治疗。分别于治疗前、治疗4周后、治疗9周后比较两组简易智能精神状态检查量表(mini-mental state examination,MMSE)、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、日常生活活动能力量表(activity of daily living,ADL)和卒中专用生存质量量表(stroke-specific quality of life scale,SS-QOL)的评分变化。结果治疗4周后,两组MMSE、MoCA、ADL和SS-QOL评分均较同组治疗前升高(P<0.05),且观察组优于对照组(P<0.05)。治疗9周后,两组MMSE、MoCA、ADL和SS-QOL评分均较同组治疗4周后升高(P<0.05),且观察组优于对照组(P<0.05)。观察组总有效率为93.8%,高于对照组的83.9%,组间差异具有统计学意义(P<0.05)。结论方氏头针联合口服盐酸多奈哌齐片治疗轻中度缺血性卒中后认知功能障碍可提高临床疗效,改善患者的认知功能和生活质量。
Objective To observe the clinical efficacy of FANG’s scalp acupuncture plus oral Donepezil hydrochloride tablets in treating mild-to-moderate cognitive dysfunction after ischemic stroke.Method Sixty-six patients with mild-to-moderate cognitive dysfunction after ischemic stroke were randomized into an observation group(33 cases including 1 dropout case)and a control group(33 cases including 1 dropout and 1 rejection cases).Both groups were prescribed conventional pharmaceutical treatment and sports rehabilitation training.The control group received daily oral Donepezil hydrochloride tablets before bedtime,and the observation group received additional FANG’s scalp acupuncture treatment.Before treatment and after 4 and 9 weeks of treatments,the scores of mini-mental state examination(MMSE),Montreal cognitive assessment(MoCA),activity of daily living(ADL),and stroke-specific quality of life scale(SS-QOL)were compared.Result After 4-week treatments,the MMSE,MoCA,ADL,and SS-QOL scores increased in both groups(P<0.05),and the observation group surpassed the control group(P<0.05).After 9-week treatments,the MMSE,MoCA,ADL,and SS-QOL scores increased in both groups compared with those at treatment week 4(P<0.05),and the observation group outperformed the control group(P<0.05).The total effective rate was 93.8%in the observation group,higher than 83.9%in the control group,and the between-group difference was statistically significant(P<0.01).Conclusion FANG’s scalp acupuncture plus oral Donepezil hydrochloride tablets can enhance clinical efficacy and improve the patient’s cognitive dysfunction and quality of life in treating mild-to-moderate cognitive impairment after ischemic stroke.
作者
刘艳芳
毛浩亮
刘媛媛
王之湄
安军明
LIU Yanfang;MAO Haoliang;LIU Yuanyuan;WANG Zhimei;AN Junming(Xi’an Hospital of Traditional Chinese Medicine,Xi’an 710021,China;Ningbo Haishu District No.2 Hospital,Ningbo 315153,China;Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《上海针灸杂志》
CSCD
2023年第4期331-335,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
陕西省中医药管理局项目(2021-01-22-007)
西安市卫生健康委员会项目(2020yb26)
陕西省方氏头针重点研究室项目[陕中医药发(2018)32号]
陕西省名老中医药专家传承工作室建设项目[陕中医药发(2018)40号]
陕西省中医药管理局重点学科项目[市卫计发(2018)27号]
西安市方氏头针传承工作室项目[市卫计函(2018)699号]。
关键词
针刺疗法
头针
针药并用
脑梗死
中风后遗症
认知功能障碍
Acupuncture therapy
Scalp acupuncture
Acupuncture medication combined
Cerebral infarction
Post-stroke sequelae
Cognitive dysfunction
