摘要
本研究旨在优选附子的蒸制及干燥工艺。以效/毒比、外观性状和水溶性浸出物的综合评价为指标,通过单因素试验结合Box-Behnken响应面法,研究蒸制时间、干燥时间和干燥温度对蒸制及干燥结果的影响,优选最佳蒸制及干燥工艺并进行验证。响应面最优工艺为:蒸制时间为4 h、干燥时间为90 min、干燥温度为105℃。优选的附子蒸制及干燥工艺稳定可靠,为陕产附子的进一步炮制研究及临床用药安全奠定基础。
To optimize the steaming and drying process parameters of the aconite.Using the comprehensive evaluation values of efficacy/toxicity ratio,appearance properties,and water-soluble extracts as indicators,the steaming time,drying time,drying temperature on the steaming and drying process were studied by the single factor test and Box-Behnken response surface methodology,and the steaming and drying process was optimized and verified.The optimal steaming and drying process was as follows,the steaming time is 4 h,drying time is 90 min,and the drying temperature is 105℃.The optimized steaming and drying process of the aconite is stable and reliable,which can lay a foundation for the further processing and research of aconite produced in Shaanxi and the safety of clinical medication.
作者
李凡
张景霞
王卫锋
李莎莎
毛阿娟
李雅娟
陈曦
李芳
LI Fan;ZHANG Jingxia;WANG Weifeng;LI Shasha;MAO Ajuan;LI Yajuan;CHEN Xi;LI Fang(Shaanxi Provincial Traditional Chinese Medicine Research Institute,Xi'an 710003,China;Xi'an International Medical Center,Xi'an 710119,China;Shaanxi University of Chinese Medicine,Xianyang 712046,China)
出处
《特产研究》
2023年第2期20-25,共6页
Special Wild Economic Animal and Plant Research
基金
陕西省科技计划项目(2020SF-325)。
关键词
附子
炮制
蒸制
干燥
生物碱
Box-Behnken响应面法
aconite
processing technology
steaming process
drying process
alkaloid
Box-Behnken response surface methodology
