摘要
目的 通过中医传承辅助平台,挖掘宋金元时期医学文献中治疗胎漏、胎动不安的用药规律。方法 收集整理宋金元时期医学文献中有关胎漏、胎动不安的处方397首,分别录入中医传承辅助平台软件,通过软件中不同板块,挖掘此时期医学文献中治疗胎漏、胎动不安的用药规律。结果 对397首处方进行药物频次分析,前十味使用的药物分别是:当归、川芎、阿胶、人参、熟地黄、白芍、白术、艾叶、炙甘草、甘草;高频药物功效分析显示以“补血药、补气药、活血化瘀药”为主;四气分析显示以温、平性为主,其次为寒性;五味中以“甘、辛”为主,其次为苦;药物归经以“肝、脾经”为主,心、肾经次之;通过用药模式分析(支持度>15%,置信度为0.9),共有7味核心药物,分别是当归、白芍、川芎、熟地黄、艾叶、阿胶、人参;“规则分析”中置信度设为0.9,提取出4条药物组合规则。基于熵层次聚类分析的组方规律(相关度设为6,惩罚度设为2)得到5首新处方。结论 宋金元时期医家多认为本病病因归于“虚、瘀”,病位着重于“肝、脾”,其次为“肾、心”,核心用药以当归芍药散加减为主,养血补血的基础上,兼以活血化瘀,标本兼施,治病与安胎并举。
Objective Through the auxiliary platform of Traditional Chinese Medicine Inheritance, this paper excavates the law of using medicine to treat fetal fistula and Dyskinesia in the medical literature of Song, Jin and Yuan dynasties.Methods 397 prescriptions about fetal leakage and Dyskinesia in the medical literature of the Song, Jin and Yuan dynasties were collected and recorded into the software of TCM transmission assistant platform, explore the medical literature of this period in the treatment of fetal leakage, fetal movement restlessness law. Results The frequency of 397 prescriptions was analyzed. The top ten drugs were Angelica Sinensis, ligusticum Chuanxiong, donkey-hide Gelatin,Ginseng, Radix Rehmanniae, Radix paeoniae Alba, atractylodis macrocephalae, folium artemisiae Argyi, radix glycyrrhizae, radix glycyrrhizae;High-frequency drug efficacy analysis showed that the main drugs were "Blood tonic, Qi tonic, activating blood circulation and removing blood stasis";Four-gas analysis showed that temperature and flatness were the main factors, followed by cold, "Gan" and "Xin" were the main factors, followed by bitter;"Liver and Spleen Meridians" were the main channel for Drug Tropism, followed by heart and Kidney Meridians;Through the analysis of drug use pattern(support & GT;15%, confidence 0.9), there were 7 core drugs, namely Angelica Sinensis, radix paeoniae alba, Ligusticum Chuanxiong, Radix Rehmanniae preparata, Artemisia Argyi, donkey-hide Gelatin, Ginseng;In "Rule analysis", the confidence level was set to 0.9, and 4 drug combination rules were extracted. Based on the entropy hierarchical clustering analysis, five new prescriptions were obtained by setting the correlation degree to 6 and the penalty degree to 2. Conclusion During the Song, Jin and Yuan Dynasties, most doctors believed that the cause of the disease was due to "Deficiency and stasis", with the focus on "Liver" and "Spleen", followed by "Kidney" and "Heart",treatment of both diseases and placentation of the fetus.
作者
马丽亚
蔡园园
张大伟
Ma Liya;Cai Yuanyuan;Zhang Dawei(Academic Affairs Office of Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Hospital of Traditional Chinese Medicine,Zhengzhou 450000,China;The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450008,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2022年第11期4484-4492,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省卫生健康委员会中医药科学研究专项课题重点课题(20-21ZY1053):庞氏安胎止血汤调控p38MARK信号通路对热症自然流产大鼠蜕膜组织Th1/Th2平衡的影响,负责人:马丽亚
河南省卫生健康委员会河南省中医药科学研究专项课题(2016ZY2099):宋金元时期中医妇科辨治用药规律研究,负责人:张大伟
河南省科学技术厅科技攻关重点项目(222102310139):清热安胎法通过抑制母胎界面炎症反应干预热证自然流产大鼠及调控NLRP3炎症小体通路的通路的分子机制,负责人:张大伟。
关键词
胎漏
胎动不安
中医传承辅助平台
数据挖掘
用药规律
宋金元医学文献
Fetal leakage/Fetal movement
Tradition Chinese medicine inheritance auxiliary platform
Data mining
Medication rule
Song Jin and Yuan medical literature
