摘要
目的:探究浆细胞性乳腺炎(PCM)患者外周血CD3、CD20、CD68表达及临床意义。方法:回顾性分析102例高度可疑PCM患者的临床资料,以病理检查为金标准。根据患者病理诊断结果,将PCM患者纳入PCM组(n=63),非PCM患者纳入对照组(n=39)。比较两组患者外周血CD3、CD20、CD68表达差异,使用受试者特征(ROC)曲线分析检测指标对PCM的诊断效能。将PCM患者根据疾病分期分为急性期组(n=18)、亚急性期组(n=22)、慢性期组(n=23),比较不同分期患者外周血CD3、CD20、CD68表达水平差异,使用Spearman法分析PCM患者病程与检测指标的相关性。结果:PCM组患者外周血CD3、CD20、CD68表达水平均低于非PCM组(P<0.05);ROC曲线结果显示,外周血CD3、CD20、CD68对PCM的诊断效能比较,差异有统计学意义(AUC=0.677、0.729、0.960,P<0.05);急性期患者CD3、CD20、CD68表达水平均低于亚急性期、慢性期患者(P<0.05),亚急性期与慢性期患者外周血CD3、CD20、CD68表达水平比较,差异均无统计学意义(P>0.05);PCM患者病程与外周血CD3、CD20、CD68表达水平正相关(r=0.586、0.581、0.483,P<0.05)。结论:PCM患者存在明显免疫功能紊乱,可通过外周血CD3、CD20、CD68表达水平辅助诊断PCM,且该三项指标与患者病程呈正相关关系。
Objective:To explore the expression levels and clinical significance of peripheral blood CD3,CD20 and CD68 in patients with plasma cell mastitis(PCM).Methods:The clinical data of 102 patients with highly suspicious PCM were retrospectively analyzed, with pathological examination as the gold standard.According to the diagnostic results, patients with PCM were included in PCM group(n=63),and patients without PCM were enrolled as control group(n=39).The differences in expression levels of peripheral blood CD3,CD20,and CD68 were compared between the two groups, and receiver operating characteristic(ROC) curve was used to analyze the diagnostic efficiency of the above three indicators on PCM.The patients with PCM were classified into acute stage group(n=18),subacute stage group(n=22) and chronic stage group(n=23) by means of disease staging, and the expressions of peripheral blood CD3,CD20 and CD68 in patients with different stages were compared.The correlation between disease course of PCM patients and expression levels of the above three indicators was analyzed by Spearman method.Results:The expression levels of peripheral blood CD3,CD20,and CD68 in PCM group were lower than those in non-PCM group(P<0.05).ROC curve showed that there was a statistical difference in the diagnostic efficiency of peripheral blood CD3,CD20 and CD68 on PCM(AUC=0.677,0.729,0.960,P<0.05).The expression levels of CD3,CD20,and CD68 in acute stage group were lower than those in subacute stage group and chronic stage group(P<0.05),but there were no statistical differences in the above expression levels between subacute stage group and chronic stage group(P>0.05).The disease course of patients with PCM was positively correlated with the expression levels of peripheral blood CD3,CD20 and CD68(r=0.586,0.581,0.483,P<0.05).Conclusion:Patients with PCM have obvious immune dysfunction, and the expression levels of peripheral blood CD3,CD20,and CD68 can be used to assist in the diagnosis of PCM,and the above three indicators have a certain positive correlation with the course of disease.
作者
韦丽光
韩猛
WEI Li-guang;HAN Meng(Department of Breast Surgery,First Hospital of Qinhuangdao,Qinhuangdao 066000,Hebei,China)
出处
《川北医学院学报》
CAS
2023年第2期213-216,共4页
Journal of North Sichuan Medical College
基金
2019年河北省秦皇岛市科技计划自筹经费项目(201902A136)。
