摘要
目的:研究免疫球蛋白联合美罗培南治疗新生儿败血症疗效及对患儿临床免疫水平、炎症因子变化的影响。方法:选取88例新生儿败血症患儿为研究对象,根据治疗方式不同分为对照组(n=40)和联合组(n=48)。对照组采用常规治疗+美罗培南治疗;联合组采用常规治疗+美罗培南+免疫球蛋白治疗。比较两组疗效、症状改善时间、临床免疫[T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))、免疫球蛋白(IgG、IgA、IgM)]、炎症指标[降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平差异。结果:联合组总有效率高于对照组(P<0.05);拒奶改善时间、体温改善时间、神经系统症状改善时间、血培养转阴时间、住院时间等较对照组均缩短(P<0.05)。治疗7 d后,联合组外周血CD3^(+)、CD4^(+)水平及IgG、IgA、IgM水平较对照组均升高(P<0.05),PCT、CRP、IL-6水平均降低(P<0.05);两组治疗前后的CD8^(+)水平比较,差异无统计学意义(P>0.05)。结论:免疫球蛋白联合美罗培南治疗新生儿败血症可减轻炎症,提升患儿免疫力,值得临床推广。
Objective:To study the efficacy of immunoglobulin combined with meropenem in the treatment of neonatal sepsis and its influence on clinical immunity level and inflammatory factors in children.Methods:The clinical data of 88 children with neonatal sepsis were retrospectively analyzed.According to the treatment regimens, the children were divided into control group(routine treatment+meropenem treatment, n=40) and combined group(routine treatment+meropenem+immunoglobulin treatment, n=48).The efficacy and symptom improvement time, as well as clinical immunity [T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+)),immunoglobulins(IgG,IgA,IgM)] and inflammatory indicators [procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)] were compared between the two groups.Results:The total effective rate of combined group was higher compared with that of control group(P<0.05).The improvement time of milk refusal, improvement time of body temperature, improvement time of neurological symptoms, the time of blood culture negative conversion and hospital stay in combined group were shortened compared to control group(P<0.05).The levels of peripheral blood CD3^(+)and CD4^(+)and levels of IgG,IgA and IgM of combined group were enhanced after 7 days of treatment(P<0.05),while the levels of PCT,CRP,and IL-6 were reduced(P<0.05).The level of CD8^(+)before and after treatment showed no statistical significance between both groups(P>0.05).Conclusion:The combination of immunoglobulin and meropenem in treating neonatal sepsis can significantly reduce the inflammation and improve the immunity of children, and it is worthy of clinical promotion.
作者
杨小庆
赵旭晶
李迎敏
王建强
YANG Xiao-qing;ZHAO Xu-jing;LI Ying-min;WANG Jian-qiang(Department of Neonatology,Yuncheng Central Hospital;Department of Neonatology,Yuncheng Maternal and Child Health Hospital;Department of Gastroenterology,Yuncheng Central Hospital,Yuncheng 044000,Shanxi,China)
出处
《川北医学院学报》
CAS
2023年第2期174-177,共4页
Journal of North Sichuan Medical College
基金
山西省卫生健康委科研课题(2020166)。
