摘要
目的 系统评价中国乳腺癌患者静脉血栓的危险因素。方法 检索中文数据库(CNKI、维普数据库、万方数据库、SinoMed)和英文数据库(PubMed、EMbase、Web of Science、Cochrane、Medline、EBSCO、Wiley online library),收集建库至2021-12-12发表的中国乳腺癌患者静脉血栓危险因素的文献,用RevMan5.3软件分析。结果 共纳入18篇文献,其中病例对照研究17篇,队列研究1篇,相关因素12个。Meta分析结果显示,术前危险因素:年龄(OR=0.43,95%CI为0.20~0.92)、体质量指数(OR=0.43,95%CI为0.33~0.56)、病理分期(OR=0.73,95%,CI为0.58~0.93)、诊断方法(OR=1.49,95%CI为1.23~1.81)、绝经(OR=1.39,95%CI为1.19~1.63)、冠心病(OR=2.18,95%CI为1.48~3.20)。术中危险因素:手术时间(OR=0.62,95%CI为0.48~0.80)是乳腺癌患者静脉血栓危险因素(均P<0.05)。结论 年龄≥60岁、体质量指数≥30 kg/m^(2)、病理分期Ⅲ期以上、手术切除活检、绝经、冠心病、手术时间≥2 h是乳腺癌患者静脉血栓的危险因素,新辅助化疗、深静脉置管、高血压、糖尿病作为危险因素的证据尚不充分,手术方法不是其危险因素。
Objective To systematically evaluate the risk factors of venous thrombosis in Chinese breast cancer patients.Methods Chinese databases(CNKI, CQVIP, Wanfang Database, SinoMed) and English databases(PubMed, EMbase, Web of Science, Cochrane, Medline, EBSCO, Wiley Online Library) were searched. Literatures on risk factors of venous thrombosis in Chinese breast cancer patients published between the establishment of the database and December 12, 2021 were collected, screened and analyzed by RevMan5.3 software.Results A total of 18 literatures were included, including 17 case-control studies, 1 cohort study, and 12 meta-analysis results of related factors. Preoperative risk factors: age(OR=0.43,95%CI 0.20~0.92), body index(OR0.43,95%CI 0.33~0.56). The pathological staging(OR=0.73, 95%CI 0.58~0.93) diagnosis method(OR=1.49, 95%CI 1.23~1.81) menopause(OR=1.39, 95%CI 1.19~1.63) Coronary heart disease(OR=2.18,95%CI 1.48~3.20), intraoperative risk factors: operative time(OR=0.62,95%CI 0.48-0.80) was a risk factor for venous thrombosis in breast cancer patients(all P<0.05).Conclusion Age≥60, body mass index≥30kg/m^(2), pathological stage≥Ⅲ, surgical resection, biopsy, menopausal coronary heart disease, surgical duration≥2 hours, are risk factors for venous thrombosis in breast cancer patients, neoadjuvant chemotherapy、deep vein catheterization、hypertension and diabetes as a risk factor is not sufficient evidence, surgical method is not a risk factor.
作者
王浩
侯朝铭
高静
柏丁兮
张浩
陈欢
Wang Hao;Hou Chaoming;Gao Jing;Bai Dingxi;Zhang Hao;Chen Huan(School of nursing,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《河南外科学杂志》
2023年第1期22-27,共6页
Henan Journal of Surgery
