摘要
肝细胞癌是一种高死亡率的原发性肝癌。在我国,男性肝细胞癌发病率与女性发病率之比为2:1~5:1。男性和女性在性激素通路方面的差异和雄激素/雄激素受体与HBV相互作用均可导致肝细胞癌发生性别差异。雄激素/雄激素受体致癌通路在肝细胞癌中的研究受到较大关注。本综述主要总结近年来雄激素/雄激素受体在肝细胞癌发病性别差异中致癌作用机制及其研究进展。
Hepatocellular carcinoma(HCC)is a kind of primary liver cancer with a high mortality rate.In China,the incidence ratio in males to females with HCC is 2:1–5:1.The difference in sex hormone pathways between males and females and the interaction between androgen/androgen receptors and HBV can lead to an incidence difference between males and females with HCC.Hence,the androgen/androgen receptor oncogenic pathway in hepatocellular carcinoma has received considerable attention.This review mainly summarizes the recent research progress on the androgen/androgen receptor oncogenic pathway in hepatocellular carcinoma.
作者
王瑞华
蔡仕良
柳东红
陈宏森
曹广文
WANG Ruihua;CAI Shiliang;LIU Donghong;CHEN Hongsen;CAO Guangwen(Department of Epidemiology,Jinan University,Guangzhou 510632,China;Department of Epidemiology,Naval Medical University,Shanghai 200433,China;Department of Hepatic Surgery,Eastern Hepatobiliary Surgery Hospital,Naval Medical University,Shanghai 200438,China)
出处
《肿瘤防治研究》
CAS
2023年第2期180-185,共6页
Cancer Research on Prevention and Treatment
基金
国家重点基础研究发展计划(973计划)(2015CB554000)
上海市公共卫生重点学科(GWV-10.1-XK17)
国家自然科学基金(91529305,81520108021,81673250,82003538)。
关键词
雄激素
雄激素受体
信号通路
肝细胞癌
Androgen
Androgen receptor
Signaling pathway
Hepatocellular carcinoma
