摘要
目的评价肌肉含量指标与骨密度(bone mineral density,BMD)的关联性,筛选预测绝经后女性骨质疏松(osteoporosis,OP)发生风险的最佳部位肌肉指标及其截止点。方法选取2018年1月至2021年10月贵州医科大学附院健康管理中心的1366名绝经后女性,采用DXA和BIA测量BMD和四肢骨骼肌含量(ASM),以ASM算出各肌肉含量指标:ASMI、ASM BMI及SMI。应用ROC曲线及Logistic回归分析验证肌肉指标对OP风险的预测能力及评估关联强度。结果OP组的肌肉含量低于非OP组,除腰椎BMD间的SMI和股骨颈、腰椎BMD间的内脏脂肪面积及大粗隆、全髋BMD间的ASM BMI差异无统计学意义(P>0.05),各部位不同BMD间脂肪、肌肉含量指标差异均有统计学意义(P<0.05)。Pearson分析显示,各部位BMD与SMI呈负相关(r=-0.095、-0.122、-0.195、-0.177);与ASM、ASM、ASM BMI呈正相关(r=0.369、0.298、0.085;0.366、0.297、0.066;0.366、0.369;0.362、0.360,P<0.05)。ROC曲线及Logistic分析显示ASM<17.2 kg(OR=3.699)和ASM BMI<0.74(OR=2.235)是预测绝经后女性股骨颈和腰椎OP发生风险关联强度最高的肌肉含量指标及截止点。结论ASM<17.2 kg和ASM BMI<0.74是OP的独立风险因素及预测绝经后女性股骨颈和腰椎部位发生OP风险的肌肉量指标及截止点范围。
Objective To evaluate the correlation between muscle content index and bone mineral density(BMD)of different parts,and to screen the best site of muscle content index measurement and cut-off point for predicting the risk of postmenopausal osteoporosis.Methods A total of 1366 postmenopausal women were selected from the Health Management Center of the Affiliated Hospital of Guizhou Medical University from January 2018 to October 2021.BMD and skeletal muscle content(ASM)of limbs were measured with DXA and BIA method.Muscle indexes such as ASMI,ASM BMI,and SMI were calculated from ASM.ROC curve and logistic regression analysis were used to verify the ability of muscle index to predict OP risk and to evaluate the correlation strength.Results The muscle content in OP group was lower than that in non-OP group.There was no significant difference between SMI and different BMD group in lumbar,the visceral fat area and different BMD group in femoral neck,and ASM BMI and different BMD group in greater trochanter and total hip BMD(P>0.05).There were significant differences in fat and muscle content among different BMD group(P<0.05).There was a negative correlation between BMD and SMI(r=-0.095,-0.122,-0.195,-0.177,P<0.05),and a positive correlation with ASM,ASM and ASM BMI(r=0.369,0.298,0.085/0.366,0.297,0.066/0.366,0.362/0.362,0.360,P<0.05).ROC curve and regression analysis showed that ASM<17.2 kg(OR=3.699)and ASM BMI<0.74(OR=2.235)were the highest muscle content indexes and cut-off points for predicting the risk of OP in postmenopausal women.Conclusion ASM<17.2 kg and ASM BMI<0.74 are independent risk factors of OP and muscle mass index and cut-off point range for predicting the risk of OP in postmenopausal women’s femoral neck and lumbar spine.
作者
许海娜
莫国应
朱焱
安苗苗
吴春艳
方月
冉利梅
XU Haina;MO Guoying;ZHU Yan;AN Miaomiao;WU Chunyan;FANG Yue;RAN Limei(.School of Public Health,the Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,Guiyang 550025;People’s Hospital of Libo County,Guizhou Province,Qiannan 558400,China;Health Management Center,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2023年第1期46-51,共6页
Chinese Journal of Osteoporosis
基金
贵州省卫生健康委科学技术基金项目(gzwjkj20191214)
中国健康促进基金会博士联盟项目(横向课题)
贵州医科大学附属医院2021年度临床研究课题项目(2021-GMHCT-011)。
关键词
肌肉质量指标
骨质疏松
临界值
预测
绝经后
muscle mass index
osteoporosis
cut off value
predication
post-menopause
