摘要
胃食管反流病(GERD)是消化系统常见病,其发病机制尚未完全明确,现代研究表明,脑肠肽在GERD的发病过程中有重要作用。各种脑肠肽通过调节食管下括约肌压力、内脏高敏性、胃肠道动力等机制影响GERD的发病,文章对8种脑肠肽与胃食管反流病相关的发病机制进行综述,分析当前研究GERD机制中脑肠肽的作用,可能对GERD治疗具有重要意义,为今后GERD的治疗提供更为广阔的思路。
Gastroesophageal reflux disease(GERD) is a common disease of digestive system, and its pathogenesis is not completely clear. Modern research shows that brain intestinal peptide plays an important role in the pathogenesis of GERD. Various brain gut peptides affect the pathogenesis of GERD by regulating lower esophageal sphincter pressure, visceral hypersensitivity, gastrointestinal motility and other mechanisms. This article reviews the pathogenesis of 8 brain gut peptides related to gastroesophageal reflux disease, and analyzes the role of brain gut peptides in the current study of GERD mechanism, which may be of great significance to the treatment of GERD and provide a broader idea for the treatment of GERD in the future.
出处
《大众科技》
2022年第12期114-118,共5页
Popular Science & Technology
关键词
胃食管反流病
脑肠肽
胃肠动力
食管下括约肌
gastroesophageal reflux disease
brain gut peptide
gastrointestinal motility
lower esophageal sphincter
