摘要
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)变体Delta变异株(B.1.617.2毒株),以极强的传播力迅速成为了目前世界范围的2019冠状病毒病(COVID-19)主要致病毒株。刺突蛋白作为冠状病毒的关键结构蛋白质,介导了SARS-CoV-2与靶细胞识别、结合及融合过程,与Delta变异株的高传染性密切相关。Delta变异株中刺突蛋白基因突变位点从其空间构象、表面亲水性与自由能等方面加以改变,影响了刺突蛋白与靶细胞膜的识别与融合过程,加速了结合进程。Delta变异株的分子结构及其功能研究对于COVID-19的预防及治疗至关重要。本文简述了SARS-CoV-2 Delta变异株相较于野生株的分子结构特点,着重以冠状病毒刺突蛋白为基础,回顾了中和抗体与血清之于Delta变异株的效力改变,并总结了SARS-CoV-2 Delta变异株的病毒动力学及临床特征,以期为拓宽Delta变异株分子结构功能变异研究方向,为未来COVID-19疫苗设计与应用提供思路。
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) variant Delta strain(B.1.617.2 strain),which has rapidly become one of the major virus-causing strains of the main pathogenic strains of coronavirus disease 2019(COVID-19) worldwide with strong transmissibility.As the key structure of coronavirus,the spike protein mediates the recognition,binding and fusion process of SARS-CoV-2 with target cells,and is closely related to the high infectivity of the Delta variant.The mutation site of the spike protein gene in the Delta variant was changed from its spatial conformation,surface hydrophilicity and free energy,which affected the recognition and fusion process of the spike protein and the target cell membrane,and accelerated the binding process.The molecular structure and function study of the Delta variant is crucial for the prevention and treatment of COVID-19.This paper briefly describes the molecular structure characteristics of the SARS-CoV-2 Delta variant compared to the wild strain,and focuses on the changes and in the efficacy of neutralizing antibodies and serum on the Delta variant based on the coronavirus spike protein.The viral dynamics and clinical characteristics of the SARS-CoV-2 Delta variant are expected to broaden the research direction of the molecular structure and function variation of the Delta variant and provide ideas for the design and application of future CoVID-19 vaccines.
作者
魏逸鸣
张俊文
WEI Yi-Ming;ZHANG Jun-Wen(Department of Gastroenterology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2023年第1期62-68,共7页
Chinese Journal of Biochemistry and Molecular Biology
