摘要
癌因性疲乏(CRF)病因与肿瘤本身、治疗方式、并发症、心理社会等因素相关,机制与细胞因子失调、下丘脑调节回路损坏、5-羟色胺失调、线粒体和肌肉失调、基因多态性等有关。药物治疗效果不显著,以非药物治疗为主。CRF属中医学“虚劳”范畴,病性属虚,具体表现为气血阴阳亏虚,以痰、湿、瘀、郁等为标,病位涉及五脏,其中以肝、脾、肾为主,中医药治疗CRF具有独特优势。本文对CRF的病因、机制、治疗的中西医文献加以概括分析,为临床相关研究提供参考。
The etiology of cancer-related fatigue(CRF) is related to the tumor itself, treatment methods,complications, and psychosocial factors. The mechanism is related to cytokine dysregulation, hypothalamic regulatory circuit damage, serotonin dysregulation, mitochondrial and muscle dysregulation, gene polymorphism, etc.Drug treatment effect is not significant, mainly non-drug treatment. TCM believes that CRF belongs to the category of “deficiency fatigue”, and the disease belongs to deficiency, which is characterized by deficiency of qi, blood, yin and yang, marked by phlegm, dampness, blood stasis and depression. The disease involves the five internal organs,mainly including liver, spleen and kidney. TCM has unique advantages in the treatment of CRF. This article summarized and analyzed the TCM and Western medicine literature on the etiology, mechanism, and treatment of CRF, and provided a reference for clinical treatment.
作者
程艳野
李志刚
CHENG Yanye;LI Zhigang(Henan University of Chinese Medicine,Zhengzhou 450046,China;The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450008,China)
出处
《中国中医药图书情报杂志》
2023年第1期108-112,共5页
Chinese Journal of Library and Information Science for Traditional Chinese Medicine
基金
河南省中医药科学研究专项课题(2022ZY1095)。
关键词
癌因性疲乏
病因
发病机制
治疗
综述
cancer-related fatigue
etiology
disease mechanism
treatment
review
