摘要
目目的的:探索遗忘型轻度认知功能障碍(aMCI)患者静息态默认网络(DMN)内功能连接(FC)改变及其与认知功能的关系。方法:根据纳入标准和排除标准,对40例未经治疗的aMCI患者(aMCI组)及40例认知功能正常的志愿者(对照组)行静息态功能磁共振成像(rs-fMRI)检查,对照组的性别、年龄、受教育年限与aMCI组相匹配。应用独立成分分析(ICA)方法提取2组受试者的DMN,并用SPM 12软件比较2组间DMN内FC差异,同时应用Pearson或Spearman相关性分析验证aMCI组差异脑区zFC值与神经心理学评分的相关性。结果:与对照组比较,aMCI组FC增强脑区位于右侧海马旁回、左侧岛叶、左侧扣带回后部、左侧楔叶、右侧岛盖部额下回、左侧缘上回、左侧楔前叶及右侧中央前回;FC减弱脑区位于左侧额中回、右侧缘上回、右侧扣带回前部、右侧角回及颞中回。相关性分析显示,aMCI组左侧额中回(r=0.439,P=0.005)、右侧颞中回(r=0.422,P=0.007)、右侧海马旁回(r=0.468,P=0.002)及左侧楔前叶zFC值(r=0.482,P=0.002)与MMSE评分呈正相关;右侧扣带回前部zFC值与AVLT延迟记忆评分(r=0.362,P=0.022)、DST顺背评分(r=0.503,P=0.001)呈正相关;右侧中央前回zFC值与TMT-B评分(r=-0.450,P=0.004)呈负相关。结论论:aMCI患者DMN内发生FC异常改变与记忆力、注意力、执行功能及视听功能缺陷相关,推测DMN内FC改变可能成为早期识别和诊断AD的影像学生物指标。
Objective:To explore the altered functional connectivity(FC)within default mode network(DMN)in patients with amnestic mild cognitive impairment(aMCI)and its relationship with cognitive function.Methods:According to the inclusion criteria and the exclusion criteria,resting-state functional magnetic resonance imaging(rs-fMRI)was performed on 40 untreated aMCI patients(aMCI group)and 40 volunteers(control group)with normal cognitive function.Factors including gender,age,and education level were matched between the control group and the aMCI group.The DMN of both groups of subjects was extracted by independent component analysis(ICA).The FC differences within DMN between two groups were compared with SPM 12 software.Pearson correlation or Spearman correlation analyses were used to test the zFC values of differential brain regions and neuropsychological scores in the aMCI group.Results:Compared with the control group,the FC enhanced brain regions in the aMCI group were located in the right parahippocampal gyrus,left insula,left posterior cingulate gyrus,left cuneus,right opercular part of inferior frontal gyrus,left superior margin gyrus,left precuneus and right precentral gyrus;the FC reduced brain regions were located in the left middle frontal gyrus,right superior margin gyrus,right anterior cingulate gyrus,right angular gyrus and right middle temporal gyrus.The correlation analysis showed that the zFC values in left middle frontal gyrus(r=0.439,P=0.005),right middle temporal gyrus(r=0.422,P=0.007),right parahippocampal gyrus(r=0.468,P=0.002)and left precuneus(r=0.482,P=0.002)were positively correlated with MMSE score,and the zFC value in right anterior cingulate gyrus was positively correlated with AVLT-delayed recall score(r=0.362,P=0.022)and DST-forward score(r=0.503,P=0.001),while the zFC value in right precentral gyrus was negatively correlated with TMT-B score(r=-0.450,P=0.004).Conclusion:The abnormal FC within DMN in patients with aMCI are associated with cognitive defects in memory,attention,executive function and audio-visual function.It is speculated that FC changes within DMN may be an imaging biomarker for early recognition and diagnosis of AD.
作者
胡赛琴
赵旭
李崖雪
纪亚红
曹丹娜
李莎
吕静
张仪
王丰
HU Saiqin;ZHAO Xu;LI Yaxue;JI Yahong;CAO Danna;LI Sha;LU Jing;ZHANG Yi;WANG Feng(Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China;The First Hospital Affiliated to Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China)
出处
《康复学报》
CSCD
2023年第1期24-31,41,共9页
Rehabilitation Medicine
基金
国家自然科学基金面上项目(81973930)
黑龙江省自然科学基金面上项目(H2016081)
黑龙江省自然科学基金联合引导项目(LH2021H101)
黑龙江中医药大学研究生创新科研项目(2022yjscx027)。
关键词
遗忘型轻度认知功能障碍
静息态功能磁共振成像
默认网络
功能连接
独立成分分析
amnestic mild cognitive impairment
resting state functional magnetic resonance imaging
default mode network
functional connectivity
independent component analysis
