摘要
同一基因pre-mRNA经可变剪接(alternative splicing,AS)后能够产生不同的转录本,使得编码的蛋白在细胞中的定位、稳定性和翻译后修饰的功能发生改变,进而增强应答发育及环境胁迫的能力,富含丝氨酸-精氨酸蛋白(serine/arginine-rich proteins,SR proteins/SR)是决定可变剪接效率和准确性的一个重要剪接因子家族。该文在简要介绍SR蛋白概念、分类的基础上,首次系统综述了植物特有的SR蛋白亚家族SR-like(SR45/45a)结构特点、成员构成、亚细胞定位和转录调控功能,尤其是对于非生物胁迫应答过程中相关基因可变剪接的调控机制进行了阐述,并展望了未来植物SR-like可能的前景方向和研究内容。
Pre-mRNA from the same gene can produce different transcript isoforms after alternative splicing(AS),which changes the location,stability and post-translational modification function of the encoded protein in cells,enhancing the ability to growth&development and respond to environmental stress.Serine-arginine-rich proteins(SR proteins)is a kind of important splicing factor(SF)family that determines the efficiency and accuracy of AS.Based on a brief introduction of the concept and classification of SR proteins family,the authors systematically reviewed the structural characteristics,classification,subcellular localization and transcriptional regulation of SR-like(SR45/45a)subfamily in plant-specific SR proteins for the first time,summarized the AS regulatory mechanism of genes under biotic/abiotic stresses,and prospected several possible directions for the research of SR-like in the future.
作者
张源珊
陈冠群
郭祥鑫
唐倩雯
李清韵
申晓辉
ZHANG Yuanshan;CHEN Guanqun;GUO Xiangxin;TANG Qianwen;LI Qingyun;SHEN Xiaohui(School of Design,Shanghai Jiao Tong University,Shanghai 200240,China)
出处
《西北植物学报》
CAS
CSCD
北大核心
2023年第1期167-180,共14页
Acta Botanica Boreali-Occidentalia Sinica
基金
国家自然科学基金(31901351)
上海市自然科学基金(22ZR1428600)。
