摘要
疼痛被称为第五大生命指征,其发生发展过程涉及神经、代谢、免疫等多项生命活动。腺苷酸活化蛋白激酶(adenosine monophosphate-activated protein kinase, AMPK)是生物能量代谢的关键分子。它广泛表达和分布于各种代谢相关组织,被能量应激激活,响应于ATP消耗增加或生成减少。近年来,诸多研究表明激活AMPK通过多种通路调节疼痛,说明AMPK广泛参与了疼痛的发生发展环节。本文在目前研究基础上梳理了AMPK参与调控疼痛的机制,为AMPK作为镇痛靶点的机制研究和临床治疗提供思路。
Pain is called the fifth vital sign, and its development process involves many life activities such as nerve, metabolism and immunity. Adenosine monophosphate-activated protein kinase(AMPK) is a key molecule in bioenergy metabolism. It is widely expressed and distributed in various metabolically related tissues, and is activated by energy stress and in response to increased ATP consumption or decreased ATP production. In recent years,many studies have shown that AMPK activation regulates pain through various pathways, indicating that AMPK is widely involved in the occurrence and development of pain. This report reviews the mechanism of AMPK involvement in the regulation of inflammation and pain on the basis of existing studies, thus providing ideas for the basic research of pain mechanism and the clinical research of AMPK-related analgesia methods.
作者
张可
李元亨
王随曦
李熳
向宏春
ZHANG Ke;LI Yuanheng;WANG Suixi;LI Man;XIANG Hongchun(School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2023年第1期6-11,共6页
Chinese Journal of Pain Medicine
基金
国家自然科学基金面上项目(81973949)
湖北省自然科学基金青年项目(2021CFB268)。
