摘要
目的:探究与分析白介素和游离氨基酸在精神分裂症患者血清和脑脊液中的表达及其意义。方法:选取2020年1月-2021年12月荆门市中医医院收治的86例发作期精神分裂症患者,按照《精神残疾分级的操作性评估标准》对患者进行分级,其中轻中度患者43例,将其划分为对照组;重度患者43例,将其划分为观察组。取两组患者空腹肘静脉血,同时行腰椎穿刺取脑脊液,检测两组患者血清和脑脊液中白介素及游离氨基酸水平。结果:观察组血清和脑脊液中白介素-1β、白介素-6、白介素-12均高于对照组,差异均有统计学意义(P<0.05);观察组血清亮氨酸、异亮氨酸、苏氨酸、赖氨酸、组氨酸、色氨酸水平均低于对照组,谷氨酰胺及天冬酰胺水平均高于对照组,差异均有统计学意义(P<0.05)。结论:精神分裂症患者病情越严重,白介素、谷氨酰胺及天冬酰胺水平越高,亮氨酸、异亮氨酸、苏氨酸、赖氨酸、组氨酸、色氨酸水平越低,白介素及游离氨基酸可作为判断精神分裂症严重程度的关键指标。
Objective:To explore and analyze the expression and significance of interleukin and free amino acid in serum and cerebrospinal fluid of schizophrenia patients.Method:A total of 86 schizophrenia patients in attack stage who were admitted to Jingmen Hospital of Traditional Chinese Medicine from January 2020 to December 2021 were classified according to the Operational Assessment Standard for Classification of Mental Disability,including 43 cases of mild and moderate patients,which were divided into the control group,and 43 cases of severe patients were divided into observation group.Fasting elbow venous blood and lumbar puncture were taken in both groups,and the levels of interleukin and free amino acid in serum and cerebrospinal fluid were detected.Result:The levels of interleukin-1β,interleukin-6 and interleukin-12 in serum and cerebrospinal fluid of observation group were higher than those of the control group,the differences were statistically significant(P<0.05).The serum levels of leucine,isoleucine,threonine,ysine,histidine and tryptophan in the observation group were lower than those in the control group,while the level of glutamine and asparagine were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The more severe the condition of schizophrenic patients,the higher the levels of interleukin,glutamine and asparagine,and the lower the levels of leucine,isoleucine,threonine,lysine,histidine and tryptophan.Interleukin and free amino acids can be used as key indicators to judge the severity of schizophrenia.
作者
段小花
许琳
李蕤
DUAN Xiaohua;XU Lin;LI Rui(Jingmen Hospital of Traditional Chinese Medicine,Hubei Province,Jingmen 448000,China;不详)
出处
《中国医学创新》
CAS
2023年第4期168-171,共4页
Medical Innovation of China
基金
湖北省科技计划项目(2018-327890)
关键词
精神分裂症
脑脊液
白介素
游离氨基酸
Schizophrenia
Cerebrospinal fluid
Interleukin
Free amino acid
