摘要
目的:依替米星联合头孢他啶对重症肺炎患者病原菌清除率、血清炎症因子及血气分析指标的影响。方法:选取2019年1月-2022年1月于宜春市第二人民医院就诊的重症肺炎患者80例,采用随机数字表法分为研究组和对照组,各40例。两组均给予常规治疗,对照组采用亚胺培南西司他丁钠治疗,研究组采用依替米星联合头孢他啶治疗。比较两组临床疗效、病原菌清除率;比较两组治疗前后血清炎症因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]及血气分析指标[二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))]。结果:研究组总有效率(95.00%)与对照组(77.50%)对比明显升高(P<0.05)。研究组病原菌清除率(90.00%)与对照组(70.00%)对比明显升高(P<0.05)。治疗后研究组血清IL-1β、TNF-α及hs-CRP水平与对照组对比均明显降低(P<0.05)。治疗后研究组PaCO_(2)与对照组对比明显降低,PaO_(2)及SaO_(2)与对照组对比均明显升高(P<0.05)。结论:依替米星联合头孢他啶治疗重症肺炎的效果显著,能有效清除病原菌,降低炎症因子水平,改善动脉血气状态。
Objective:The effect of Etimicin combined with Ceftazidime on pathogen clearance rate,serum inflammatory factors and blood gas analysis indexes in patients with severe pneumonia.Method:A total of 80 patients with severe pneumonia who were treated in Yichun Second People's Hospital from January 2019 to January 2022 were selected and divided into a study group and a control group by random number table method,with 40 cases in each group.Both groups were given conventional treatment,the control group was treated with Imipenem and Cilastatin Sodium,and the study group was treated with Etimicin combined with Ceftazidime.The clinical efficacy and pathogen clearance rate were compared between the two groups.Serum inflammatory factors[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),hypersensitive C reactive protein(hs-CRP)]and blood gas analysis indexes[(partial carbon dioxide pressure(PaCO_(2)),arterial oxygen partial pressure(PaO_(2))and oxygen saturation(SaO_(2))]were compared between the two groups before and after treatment.Result:The total effective rate of the study group(95.00%)was significantly higher than that of the control group(77.50%)(P<0.05).The pathogen clearance rate in the study group(90.00%)was significantly higher than that in the control group(70.00%)(P<0.05).After treatment,the serum levels of IL-1β,TNF-αand hs-CRP in the study group were significantly decreased compared with the control group(P<0.05).After treatment,PaCO_(2)of the study group was significantly decreased compared with the control group,while PaO_(2)and SaO_(2)were significantly increased compared with the control group(P<0.05).Conclusion:The effect of Etimicin combined with Ceftazidime in the treatment of severe pneumonia is significant,which can effectively remove pathogenic bacteria,reduce the level of inflammatory factors,and improve the state of arterial blood gas.
作者
刘容
彭小玲
LIU Rong;PENG Xiaoling(Yichun Second People's Hospital,Jiangxi Province,Yichun 336000,China;不详)
出处
《中国医学创新》
CAS
2023年第4期63-67,共5页
Medical Innovation of China
关键词
依替米星
头孢他啶
重症肺炎
病原菌清除率
炎症因子
血气分析
Etimicin
Ceftazidime
Severe pneumonia
Pathogen clearance rate
Inflammatory factors
Blood gas analysis indexes
