摘要
目的探究上尿路结石患者术后发生泌尿系统感染的危险因素及血清降钙素原(PCT)、肿瘤坏死因子(TNF-α)和外周血白细胞(WBC)的预测价值。方法回顾性分析2014年6月—2021年6月北京核工业医院泌尿外科收治的118例上尿路结石行经皮肾镜碎石取石手术的患者资料。采用logistic回归分析患者术后并发泌尿系统感染的危险因素;采用ELISA法检测并发感染或未并发感染患者的血清PCT、TNF-α表达水平,并记录外周血WBC计数,采用ROC曲线评估三者对术后并发泌尿系统感染的诊断价值。结果患者结石大小、手术时长、术前尿培养阳性、尿蛋白阳性是术后并发泌尿系统感染的危险因素(P<0.05);ROC曲线结果血清PCT、TNF-α、外周血WBC及三者联合分析曲线下面积AUC分别为0.903、0.893、0.854、0.994。结论结石大小、手术时长及术前尿路感染是术后并发泌尿系统感染的危险因素,术后血清PCT、TNF-α、外周血WBC联合分析对并发泌尿系统感染的诊断效能最优。
Objective To explore the risk factors of postoperative urinary tract infection in patients with upper urinary tract calculi and the diagnostic value of serum PCT,TNF-αand WBC for postoperative urinary tract infection.Methods The data of 118 patients with upper urinary tract calculi who underwent percutaneous nephrolithotomy in the Department of Urology,Beijing Nuclear Industry Hospital from June 2014 to June 2021 were retrospectively analyzed.Logistic regression was used to analyze the risk factors of postoperative urinary tract infection in patients;serum PCT and TNF-αexpression levels in patients with or without infection were detected by ELISA,and WBC counts in peripheral blood were recorded.Diagnostic value of postoperative urinary tract infection.Results Stone size,operation time,positive urine culture and positive urine protein were the risk factors of postoperative urinary tract infection(P<0.05).AUC for PCT,TNF-α,WBC,and combined analysis curve were 0.903,0.893,0.854 and 0.994,respectively.Conclusion Stone size,operation time and preoperative urinary tract infection are the risk factors of postoperative urinary tract infection.The combined analysis of postoperative PCT,TNF-αand WBC get the best diagnostic effi cacy for urinary tract infection.
作者
庞华
边建华
刘文杰
智静涛
PANG Hua;BIAN Jian-hua;LIU Wen-jie;ZHI Jing-tao(Department of Urology,Beijing Nuclear Industry Hospital,Beijing,102413,China;Department of Urology,Liangxiang Hospital,Fangshan District,Beijing,102401,China)
出处
《中华养生保健》
2023年第4期15-18,共4页
CHINESE HEALTH CARE
关键词
上尿路结石
泌尿系统感染
经皮肾镜
upper urinary tract calculi
urinary tract infection
percutaneous nephrolithotomy
