摘要
哮喘是近几年发病率高且极常见的慢性呼吸系统疾病。许众多研究证实,环境内分泌干扰物(EED)对哮喘等呼吸系统疾病的发生发展具有重要作用。邻苯二甲酸二乙基己酯、壬基酚、双酚A和三氯生等作为EED,在哮喘发生发展过程中具有一定协调作用或类似“佐剂”作用,推进哮喘发病进程。EED对哮喘的作用机制主要包括:(1)直接损伤气道结构;(2)参与免疫调节,促进炎症细胞增殖;(3)促进辅助性T细胞2型细胞反应;(4)干扰内分泌系统功能;(5)促进氧化应激反应;(6)影响神经生长因子对免疫功能中介导嗜酸性粒细胞激活的调节作用;(7)干扰下丘脑-垂体-肾上腺轴负反馈;(8)降低微管亲和调节激酶1基因甲基化程度,推进哮喘的发生发展。本文就上述4种常见EED及其对哮喘多方面影响进行综述,为哮喘的防治提供新思路。
Asthma is a very common chronic respiratory disease with high incidence in recent years. Many studies have proved that environmental endocrine disruptors(EEDs) play an important role in the occurrence and development of many respiratory diseases, including asthma, and they can participate in the pathogenesis of asthma in multiple ways. Diethylhexane, nonylphenol, bisphenol A,triclosan and other EEDs are considered to play a coordinating role or a role similar to that of an "adjuvant" in the development of asthma, and promote the pathogenesis of asthma. The mechanisms of EEDs on asthma include:(1) causing direct damage to airway structure,(2) participating in immune regulation to promote the proliferation and development of inflammatory cells,(3) promoting T helper2 cell response,(4) interfering with endocrine system function,(5) promoting oxidative stress response,(6) influencing nerve growth factors in mediating eosinophil activation in immune function,(7) disrupting the hypothalamic-pituitary-adrenal axis, and(8) reducing the methylation of M tubular affinity kinase 1gene. This paper reviews the above four common EEDs and their multifaceted effects on asthma to provide new ideas as to how asthma can be prevented.
作者
何洁
许洁
俞捷
HE Jie;XU Jie;YU Jie(School of Public Health,Zunyi Medical University,Zunyi 563000,China)
出处
《中国药理学与毒理学杂志》
CAS
北大核心
2022年第11期872-880,共9页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(22266039)
国家自然科学基金(22166035)
贵州省高层次创新型“百层次”人才[(2022)035-1]
贵州省高层次创新型“百层次”人才[(2020)6014]。
关键词
环境内分泌干扰物
哮喘
气道炎症
气道重塑
氧化应激
environmental endocrine disruptors
asthma
airway inflammation
airway remodeling
oxidative stress
