摘要
目的:观察丹红注射液联合常规西药治疗冠心病患者的效果。方法:回顾性分析2020年1月至2022年3月该院收治的80例冠心病患者的临床资料,按治疗方法不同将患者分为对照组34例和观察组46例。对照组采用常规西药治疗,观察组在对照组基础上联合丹红注射液治疗,比较两组临床疗效、治疗前后血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度及红细胞聚集指数)水平、冠状动脉微循环指标[冠状动脉血流储备(CFR)、微循环阻力指数(IMR)]水平、心率变异性指标[全程相邻RR间期之差的平方根(RMSSD)、相邻RR间期差值超过50 ms的个数占总窦性心搏个数的百分比(PNN50)、正常RR间期的标准差(SDNN)、5 min均值标准差(SDANN)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.65%(44/46),高于对照组的76.47%(26/34),差异有统计学意义(P<0.05);治疗后,两组全血高切黏度、全血低切黏度、血浆黏度和红细胞聚集指数等血液流变学指标水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IMR水平均低于治疗前,且观察组低于对照组,两组CFR水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组RMSSD、PNN50、SDNN和SDANN等心率变异性指标水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丹红注射液联合常规西药治疗冠心病患者可提高治疗总有效率,纠正心率变异性,改善冠状动脉微循环和血液流变学指标水平,效果优于单纯常规西药治疗。
Objective: To observe the effect of Danhong injection combined with conventional Western medicine on patients with coronary heart disease. Methods: The clinical data of 80 patients with coronary heart disease admitted to this hospital from January 2020 to March 2022were retrospectively analyzed. These patients were divided into control group(34 cases) and observation group(46 cases) according to different treatment methods. The control group was treated with conventional Western medicine, while the observation group was treated with Danhong injection on the basis of that of the control group. The clinical efficacy, the hemorheology index levels(whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and erythrocyte aggregation index), the coronary microcirculation index levels [coronary flow reserve(CFR),microcirculation resistance index(IMR)], the heart rate variability index levels [square root of the difference between adjacent RR intervals(RMSSD),percentage of the number of adjacent RR interval differences exceeding 50 ms in the total number of sinus beats(PNN50), standard deviation of normal RR intervals(SDNN), standard deviation of 5 min mean(SDANN)], and the incidence of adverse reactions were compared between the two groups before and after the treatment. Results: The total effective rate of treatment in the observation group was 95.65%(44/46), which was higher than 76.47%(26/34) in the control group, and the difference was statistically significant(P<0.05). After the treatment, the levels of hemorheology indexes such as whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and erythrocyte aggregation index in the two groups were lower than those before the treatment, those in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). After the treatment, the IMR levels of the two groups were lower than those before the treatment, and that of the observation group was lower than that of the control group;the CFR levels of the two groups were higher than those before the treatment, and that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05). After the treatment, the levels of heart rate variability indexes such as RMSSD, PNN50, SDNN and SDANN in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions: Danhong injection combined with conventional Western medicine can improve the total effective rate and the heart rate variability index levels, improve the levels of coronary microcirculation indexes, and reduce the levels of hemorheology indexes in the patients with coronary heart disease. Moreover, it is superior to single conventional Western medicine treatment.
作者
徐丽丹
XU Lidan(Department of Internal Medicine of Jiamusi Infectious Diseases Hospital,Jiamusi 154002 Heilongjiang,China)
出处
《中国民康医学》
2023年第1期96-98,102,共4页
Medical Journal of Chinese People’s Health
关键词
丹红注射液
冠心病
血液流变学
冠状动脉微循环
心率变异性
Danhong injection
Coronary heart disease
Hemorheology
Coronary microcirculation
Heart rate variability
