摘要
本研究对常用抗菌药物穿透血脑屏障的能力进行总结,探讨老年康复患者血脑屏障特点及药物选择,发现β-内酰胺类、三代头孢菌素类、糖肽类抗菌药物可有效透过血脑屏障,达到有效药物浓度,老年患者可安全使用。
Through summarizing and analyzing the common antibacterial drugs,we found the abilities of differens blood-brain barrier permeability rate and its influencing factors.Blood-brain barrier impairment is the most common age-associated neuropathological changes.We found thatβ-Lactam antibiotics,third-generation cephalosporins and glycopeptide antibiotics were widely used in the elderly recovered patients because of the lower toxicity and better ability to penetration into cerebrospinal fluid in the presence of meningitis.
作者
段文琪
陈明辉
DUAN Wenqi;CHEN Minghui(Department of Pharmacy,Beijing Xiaotangshan Hospital,Beijing 102211;Department of Pharmacy,Beijing Hospital,National Center of Gerontology,Assessment of Clinical Drugs Risk and Individual Application Key Laboratory,Beijing 100730,China)
出处
《中国老年保健医学》
2022年第6期33-35,共3页
Chinese Journal of Geriatric Care
关键词
抗菌药物
血脑屏障
药物浓度
Antibacterial drugs
Blood brain barrier
Drug concentration
