摘要
目的 分析孟鲁司特钠联合糖皮质激素治疗中老年哮喘的效果。方法 30例中老年哮喘患者,采用随机数字表法分为常规组和研究组,每组15例。常规组患者采用糖皮质激素治疗,研究组患者采用孟鲁司特钠联合糖皮质激素治疗。比较两组治疗前后呼气峰值流速、第1秒用力呼气容积、哮喘控制测试(ACT)评分、超敏C反应蛋白水平,治疗效果。结果 治疗前,两组患者呼气峰值流速、第1秒用力呼气容积、ACT评分、超敏C反应蛋白水平比较差异均无统计学意义(P>0.05);治疗后,两组呼气峰值流速、第1秒用力呼气容积、ACT评分、超敏C反应蛋白水平均较治疗前改善,且研究组呼气峰值流速(5.72±1.12)L/s、第1秒用力呼气容积(3.34±0.38)L、ACT评分(24.34±0.34)分显著高于常规组的(4.52±1.21)L/s、(2.44±0.21)L、(21.45±0.25)分,超敏C反应蛋白(7.31±1.38)mg/L显著低于常规组的(9.35±1.67)mg/L,差异具有统计学意义(P<0.05)。研究组患者的治疗总有效率100.00%高于常规组的66.67%,差异具有统计学意义(P<0.05)。结论 孟鲁司特钠联合糖皮质激素对于中老年哮喘患者的治疗效果确切,值得推广。
Objective To analyze the effect of montelukast sodium combined with glucocorticoid in the treatment of asthma in middle-aged and elderly patients. Methods A total of 30 middle-aged and elderly patients with asthma were randomly divided into the conventional group and the research group, with 15 patients in each group. Patients in the conventional group were treated with glucocorticoid, and patients in the research group were treated with montelukast sodium and glucocorticoid. Both groups were compared in terms of peak expiratory flow, forced expiratory volume in one second, asthma control test(ACT) score, and high-sensitivity C-reactive protein before and after treatment. Results Before treatment, there was no statistically significant difference between the two groups in terms of peak expiratory flow, forced expiratory volume in one second, ACT score, and high-sensitivity C-reactive protein(P>0.05). After treatment, the peak expiratory flow, forced expiratory volume in one second, ACT score, and high-sensitivity C-reactive protein in the two groups were better than those before treatment in this group;the research group had peak expiratory flow of(5.72±1.12) L/s, forced expiratory volume in one second of(3.34±0.38) L, ACT score of(24.34±0.34) points, which were significantly higher than(4.52±1.21) L/s,(2.44±0.21) L,(21.45±0.25) min in the conventional group;the high-sensitivity C-reactive protein(7.31±1.38) mg/L in the research group significantly lower than(9.35±1.67) mg/L in the conventional group;the differences were statistically significant(P<0.05). The total effective rate 100.00% in the research group was higher than 66.67% in the conventional group, and the difference was statistically significant(P<0.05).Conclusion Montelukast sodium combined with glucocorticoid in the treatment of asthma in middle-aged and elderly patients is effective, and is worthy of promotion.
作者
杨艳薇
YANG Yan-wei(Department of Respiratory Medicine,Nuclear Industry General Hospital of Xingcheng Health Industry Group,Xingcheng 125100,China)
出处
《中国现代药物应用》
2023年第1期131-133,共3页
Chinese Journal of Modern Drug Application
关键词
孟鲁司特钠
糖皮质激素
中老年哮喘
布地奈德
Montelukast sodium
Glucocorticoid
Asthma in middle-aged and elderly
Budesonide
