摘要
目的分析儿童肺炎链球菌(SP)感染的临床特征和耐药性。方法选取100例肺炎链球菌感染患儿作为观察组,另选取100例健康体检儿童作为对照组。分析观察组患儿临床特征及耐药性,比较两组白细胞计数、中性粒细胞百分比以及血清C反应蛋白(CRP)水平。结果100例肺炎链球菌感染患儿中,≤2岁患儿的发病率较高,共62例,占比为62.00%;冬季是发病率最高的季节,共38例,占比为38.00%,其次为春季,共32例,占比为32.00%;标本分布以痰标本为主,共88例,占比为88.00%;肺炎是发病率最高的疾病类型,共70例,占比为70.00%。100株肺炎链球菌对红霉素的耐药率最高(95.00%),对厄他培南、万古霉素、利奈唑胺的敏感率最高(100.00%)。观察组白细胞计数(11.59±3.25)×109/L、中性粒细胞百分比(47.55±9.64)%和CRP(29.76±9.63)mg/L均高于对照组的(7.48±2.51)×109/L、(42.33±13.25)%、(7.58±3.57)mg/L,差异具有统计学意义(P<0.05)。结论冬季是发生儿童肺炎链球菌感染的主要季节,且感染人群以≤2岁患儿为主,在肺炎链球菌感染的治疗中红霉素有着较高的耐药率,不适合在当前的临床治疗中应用。
Objective To analyze the clinical characteristics and drug resistance analysis of Streptococcus pneumoniae(SP) infection in children. Methods 100 children with Streptococcus pneumoniae infection were selected as the observation group, and another 100 children with healthy physical examination were selected as the control group. The clinical characteristics and drug resistance of the children in the observation group were analyzed, and the white blood cell counts, neutrophil percentages and serum C-reactive protein(CRP) levels of the two groups were compared. Results Among the 100 children with Streptococcus pneumoniae infection, the incidence rate was higher in children ≤2 years old, with 62 cases, accounting for 62.00%;winter was the season with the highest incidence rate, with 38 cases, accounting for 38.00%, followed by spring, with 32 cases, accounting for 32.00%;the distribution of specimens was dominated by sputum specimens, with 88 cases, accounting for 88.00%;pneumonia was the disease type with the highest incidence rate, with 70 cases, accounting for 70.00%. The 100 strains of Streptococcus pneumoniae showed the highest resistance to erythromycin(95.00%) and the highest sensitivity to ertapenem, vancomycin, and linezolid(100.00%). The leukocyte count(11.59±3.25)×10~9/L, neutrophil percentage(47.55±9.64)% and CRP(29.76±9.63) mg/L in the observation group were higher than(7.48±2.51)×10~9/L,(42.33±13.25)% and(7.58±3.57) mg/L in the control group, and the differences were statistical significance(P<0.05). Conclusion Winter is the main season for Streptococcus pneumoniae infection in children, and the infected population is mainly children ≤2 years old.In the treatment of Streptococcus pneumoniae infection, erythromycin has a high resistance rate and is not suitable for application in current clinical treatment.
作者
李水娟
郭文君
吴童
LI Shui-juan;GUO Wen-jun;WU Tong(Department of Pediatrics,Bao'an District Songgang People's Hospital Pediatrics,Shenzhen 518000,China)
出处
《中国现代药物应用》
2023年第1期38-41,共4页
Chinese Journal of Modern Drug Application
关键词
儿童肺炎链球菌
感染
临床特征
耐药性
Streptococcus pneumoniae in children
Infection
Clinical characteristics
Drug resistance
