摘要
僵直少动型帕金森病(AR-PD)病人更易出现运动障碍且预后较差。多模态影像技术为评估PD病人大脑结构及功能改变提供了无创手段。经颅磁刺激(TMS)作为一种无创的治疗方法,可以通过改变刺激脑区的兴奋性达到改善PD运动症状的效果。总结AR-PD的临床特征,并就基于磁敏感加权成像、结构MRI、血氧水平依赖功能MRI和扩散张量成像等多模态MRI以及核医学技术对AR-PD的脑机制及其在AR-PD TMS治疗中的研究进展予以综述。
Akineto-rigid Parkinson’s disease(AR-PD) patients are more prone to movement disorders and have a worse prognosis. Multimodal imaging technology provides a non-invasive method for evaluating the structural and functional changes of the brain in patients with PD. Transcranial magnetic stimulation(TMS), as a non-invasive treatment method, can relieve the motor symptoms of PD by changing the excitability of the stimulated brain areas. The clinical characteristics of AR-PD were summarized, and the brain mechanism of AR-PD and research progress in the TMS treatment of AR-PD were reviewed based on multimodal MRI techniques such as magnetic sensitive weighted imaging, structural MRI, oxygen-dependent functional MRI, diffusion tensor imaging, and nuclear medicine techniques.
作者
杨燕
白岩
魏焕焕
王梅云
YANG Yan;BAI Yan;WEI Huanhuan;WANG Meiyun(Department of Medical Imaging,People’s Hospital of Zhengzhou University,Zhengzhou 450003,China;Henan Provincial People’s Hospital,Henan Key Laboratory of Neurological Imaging)
出处
《国际医学放射学杂志》
北大核心
2023年第1期31-35,共5页
International Journal of Medical Radiology
基金
国家自然科学基金(81720108021)。
关键词
帕金森病
僵直
多模态影像技术
经颅磁刺激
Parkinson’s disease
Rigidity
Multimodal imaging technology
Transcranial magnetic stimulation
