摘要
有机氟化物具有独特的物理、化学性质及生理活性,在医学、农业化学、材料科学等领域引起了广泛关注。本文综述了氟气直接氟化、Balz-Schiemann反应、亲核氟化、亲电氟化和自由基氟化等氟化反应的优缺点,旨在为相关有机氟化物的化学合成提供新思路。
Organic fluorides often have unique physical,chemical properties and physiological activities,and have attracted much attention in the fields of medicine,agro-chemistry,materials science and so on.To provide new ideas for the chemical synthesis of the related organic fluorides,the advantages and disadvantages of five kinds of fluorination reactions,including direct fluorination by fluorine gas,Balz-Schiemann reaction,nucleophilic fluorination,electrophilic fluorination and radical fluorination were summaried in this paper.
作者
杨艳丽
马耀
李惠静
吴彦超
YANG Yan-li;MA Yao;LI Hui-jing;WU Yan-chao(Weihai Marine Organism&Medical Technology Research Institute,Harbin Institute of Technology,Weihai 264209,China)
出处
《化学研究与应用》
CAS
北大核心
2023年第1期10-20,共11页
Chemical Research and Application
基金
国家自然科学基金项目(21672046,21372054)资助。
关键词
碳氟有机物
亲电氟化
亲核氟化
自由基氟化
fluorocarbon organics
electrophilic fluorination
nucleophilic fluorination
radical fluorination
