摘要
脓毒症仍为21世纪医学的重要挑战之一。二肽基肽酶Ⅲ(DPP3)是新发现的与脓毒症相关的生物标志物,在人体内主要降解血管紧张素Ⅱ(AngⅡ),它不仅可以抑制心脏的收缩功能,而且还能够降低血管张力,从而引起心输出量不足、血压降低,导致脓毒症患者发生休克和多器官功能损害。因此DPP3或将成为脓毒症治疗的新靶点。
Sepsis is still one of the important challenges of medicine in the 21st century.Dipeptide peptidaseⅢ(DPP3)is a new biomarker associated with sepsis,which mainly degrades angiotensinⅡin human body.It can not only inhibit cardiac systolic function,but also reduce vascular tension,resulting in insufficient cardiac output and low blood pressure,resulting in shock and multiple organ dysfunctions in patients with sepsis.Therefore,DPP3 may become a new target for sepsis treatment.
作者
王英臣
孙立群
WANG Yingchen;SUN Liqun(Intensive Care Unit,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China)
出处
《基础医学与临床》
2023年第1期196-199,共4页
Basic and Clinical Medicine
基金
江苏省卫生健康委科研项目(M2020045)
789人才项目(789ZYRC202070317)。
