摘要
间充质干细胞可以通过旁分泌各种细胞因子减轻炎性反应和恢复肾脏损伤,以及通过调控免疫细胞维持免疫稳态。临床前研究表明,间充质干细胞对急性肾损伤、糖尿病肾病、狼疮性肾炎及各种肾小球疾病动物模型均有明显的治疗效果。临床研究中也证明了间充质干细胞治疗人类肾病是安全、有效的。间充质干细胞疗法揭开了肾脏疾病领域新的生物治疗模式。
Mesenchymal stem cells(MSCs)can reduce inflammation,restore renal injury and maintain immune homeostasis by paracrine various cytokines and regulating immune cells.In preclinical studies,it has been proved that mesenchymal stem cells have obvious therapeutic effects on acute kidney injury,diabetic nephropathy,lupus nephritis and various glomerular diseases in animal models.In clinical studies,mesenchymal stem cells have also been shown to be safe and partially effective.Mesenchymal stem cell therapy has revealed a new model of biotherapy in kidney diseases.
作者
杨蕴钊
石美涵
周诚
白雪源
YANG Yunzhao;SHI Meihan;ZHOU Cheng;BAI Xueyuan(Department of Nephrology,First Medical Center of Chinese PLA General Hospital,Chinese PLA Institute of Nephrology,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing 100853,China)
出处
《基础医学与临床》
2023年第1期30-37,共8页
Basic and Clinical Medicine
基金
国家重点研发计划(2020YFA0113004)
国家自然科学基金重点项目(81830060)。
关键词
间充质干细胞
肾脏疾病
免疫反应
mesenchymal stem cells
nephropathy
immune response
