摘要
目的评估粪菌移植(fecal microbiota transplantation,FMT)治疗肠易激综合征(irritable bowel syndrome,IBS)的效果。方法计算机检索PubMed、Embase、Cochrane Library、知网、万方、生物医学期刊文献数据库、维普等电子数据库,获取建库以来所有关于FMT治疗IBS的临床研究,严格筛选出符合要求的研究,提取数据并进行文献评价,最后进行Meta分析。结果共有9篇文献纳入Meta分析,包含569例IBS患者。Meta分析结果显示:(1)FMT组在缓解IBS临床症状方面并不优于对照组,组间差异无统计学意义(RR=1.33,95%CI:0.92~1.92,P=0.13;I^(2)=76%);(2)FMT组与对照组比较,不能明显改善IBS-SSS评分,组间差异无统计学意义(SMD=-0.19,95%CI:-1.13~0.75,P=0.69;I^(2)=92%)。亚组分析提示:经中、下消化道行FMT组与对照组相比,IBS临床症状缓解更明显(RR=1.68,95%CI:1.22~2.32,P=0.001),但经上消化道行FMT则不能缓解IBS临床症状(RR=0.62,95%CI:0.35~1.10,P=0.11)。结论经中、下消化道行FMT可以有效缓解IBS临床症状,但经上消化道行FMT治疗IBS效果不明显。
Objective To evaluate the efficacy of fecal microbiota transplantation(FMT)on irritable bowel syndrome(IBS).Methods Electronic databases,such as PubMed,Embase,Cochrane Library,CNKI,Wanfang,CBM and VIP,were searched to obtain all the clinical studies on FMT for treating IBS from inception of the databases.Studies met the inclusion and exclusion criteria were strictly screened out.Data were extracted and quality of the included studies were evaluated.Finally,a Meta-analysis was conducted.Results A total of 9 studies with 569 IBS patients were included.We found:(1)efficacy of FMT group was not better than that of control group in alleviating the clinical symptoms of IBS,and there was no significant difference between two groups(RR=1.33,95%CI:0.92-1.92,P=0.13;I^(2)=76%);(2)compared with control group,FMT could not improve IBS-SSS score,and there was no significant difference between two groups(SMD=-0.19,95%CI:-1.13-0.75,P=0.69;I^(2)=92%).Subgroup analysis indicated:compared with control group,the clinical symptoms of IBS improved more in FMT group delivered through middle and lower gastrointestinal tract(RR=1.68,95%CI:1.22-2.32,P=0.001),but not in FMT group delivered through upper gastrointestinal tract(RR=0.62,95%CI:0.35-1.10,P=0.11).Conclusion FMT delivered through middle and lower gastrointestinal tract could effectively relieve the clinical symptoms of IBS,but not in FMT delivered through upper gastrointestinal tract.
作者
邢寒阳
陈东风
但凤
XING Hanyang;CHEN Dongfeng;DAN Feng(Department of Gastroenterology,Daping Hospital,Army Medical University,Chongqing 400042;Department of Critical Care Medicine,Chongqing Orthopedic Hospital of Traditional Chinese Medicine,China)
出处
《胃肠病学和肝病学杂志》
CAS
2022年第11期1234-1240,共7页
Chinese Journal of Gastroenterology and Hepatology
关键词
粪菌移植
肠易激综合征
治疗
META分析
Fecal microbiota transplantation
Irritable bowel syndrome
Treatment
Meta-analysis
