摘要
目的比较基于“俞募配穴”理论的穴位埋线疗法与穴位针刺治疗大肠湿热型溃疡性结肠炎(UC)的疗效。方法将我院2019年1月-2020年12月收治的80例大肠湿热型轻-中度活动性UC患者随机分为观察组和对照组,各40例。两组均口服美沙拉嗪肠溶片作为基础治疗,对照组予以穴位针刺疗法治疗,观察组予以穴位埋线疗法治疗。比较两组临床疗效、临床症状评分、电子结肠镜表现、外周血中核转录因子κB(NF-κB)、Toll样受体4(TLR4)蛋白及其mRNA表达水平。结果观察组总有效率为87.50%,高于对照组的65.00%,差异有统计学意义(P<0.05);观察组腹痛、脓血便、腹泻评分、Sourtherland疾病活动指数(DAI)评分、结肠镜表现评分,NF-κB、TLR4蛋白相对表达量及NF-κBmRNA、TLR4mRNA表达水平低于对照组,差异有统计学意义(P<0.05)。结论基于“俞募配穴”理论的穴位埋线疗法治疗大肠湿热型轻-中度活动性UC疗效优于针刺疗法,可改善患者临床症状,促进病变黏膜修复,其作用机制可能与NF-κB和TLR4 mRNA和蛋白的下调有关。
Objective To compare the efficacy of point catgut-embedding therapy based on the theory of"Shu and Mu Adjunct Acupuncture Points"and acupoint acupuncture in the treatment of ulcerative colitis(UC)of damp-heat type of large intestine.Methods A total of 80 patients with mild to moderate active UC of damp-heat type of large intestine admitted to our hospital from January 2019 to December 2020 were randomly divided into observation group and control group,with 40 cases in each group.Both groups were given oral mesalazine enteric-coated tablets as basic treatment.The control group was treated with acupoint acupuncture therapy,and the observation group was treated with point catgut-embedding therapy.The clinical efficacy,clinical symptom score,electronic colonoscopy performance,nuclear transcription factorκB(NF-κB),Toll-like receptor 4(TLR4)protein and mRNA expression levels in peripheral blood were compared between the two groups.Results The total effective rate of the observation group was 87.50%,which was higher than 65.00%of the control group,and the difference was statistically significant(P<0.05).The abdominal pain,purulent bloody stool,diarrhea score,Sourtherland disease activity index(DAI)score,colonoscopy performance score,relative expression of NF-κB and TLR4 protein and expression levels of NF-κB mRNA and TLR4 mRNA in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The point catgut-embedding therapy based on the theory of"Shu and Mu Adjunct Acupuncture Points"is superior to acupuncture therapy in the treatment of mild to moderate active UC of damp-heat type of large intestine,which can improve the clinical symptoms of patients and promote the repair of diseased mucosa.The mechanism may be related to the down-regulation of NF-κB and TLR4 mRNA and protein.
作者
刘淼
杜强
毛刚
张帆
周雪雷
万学梅
LIU Miao;DU Qiang;MAO Gang;ZHANG Fan;ZHOU Xue-lei;WAN Xue-mei(Department of Spleen and Gastrointestinal Diseases,Affiliated Hospital of Chengdu University of Chinese Medicine,Chengdu 610013,Sichuan,China)
出处
《医学信息》
2022年第23期143-146,共4页
Journal of Medical Information
基金
成都市科技局课题(编号:2018-YFYF-000555-SN)。
关键词
溃疡性结肠炎
大肠湿热
俞募配穴
埋线疗法
NF-κB
TLR4
Ulcerative colitis
Damp-heat type of large intestine
Shu and Mu Adjunct Acupuncture Points
Catgut-embedding therapy
NF-κB
TLR4
