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阿尔茨海默病患者伴嗅觉障碍的影响因素分析及防治策略 被引量:3

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摘要 目的:探讨阿尔茨海默病(AD)患者伴嗅觉障碍的影响因素分析及防治策略。方法:回顾性分析2019年11月—2021年12月于我院接受治疗的126例AD患者的临床资料,根据AD患者是否伴发嗅觉障碍分为嗅觉障碍组和非嗅觉障碍组,采用单因素以及多因素Logistic回归分析筛选AD伴发嗅觉障碍的相关危险因素,并提出相应防治措施。结果:126例AD患者中40例发生了嗅觉障碍,发生率为31.75%,86例AD患者未发生嗅觉障碍;两组患者性别、居住地、婚姻状态、病程、BMI、饮酒史、高血压、糖尿病、冠心病、SDS评分、HDL-C、LDL-C以及TNF-α对比差异无统计学意义(P>0.05),而患者年龄、吸烟史、文化程度、PSQI评分、Ach对比差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,吸烟史是AD患者发生嗅觉障碍的保护因素,而年龄、文化程度、PSQI评分、Ach均为AD患者发生嗅觉障碍的独立危险因素(P<0.05)。结论:AD患者并发嗅觉障碍与患者年龄、吸烟史、文化程度、PSQI评分、Ach等密切相关,临床治疗期间可根据上述5项危险因素制定针对性的干预措施,进而降低嗅觉障碍发生率,提高患者临床疗效。
出处 《医学理论与实践》 2023年第2期228-231,共4页 The Journal of Medical Theory and Practice
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