摘要
目的:观察金丹盆乐汤保留灌肠联合克林霉素治疗慢性盆腔炎(CPID)患者的效果。方法:选取2019年1月至2021年12月该院收治的72例CPID患者进行前瞻性研究,按照随机数字表法分为对照组35例和观察组37例。对照组给予克林霉素治疗,观察组在对照组基础上联合金丹盆乐汤保留灌肠治疗。比较两组治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)]水平、盆腔积液深度、盆腔包块直径和血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度)水平,以及不良反应发生率。结果:治疗后,两组TNF-α水平均低于治疗前,且观察组低于对照组,两组IL-2水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组盆腔积液深度均低于治疗前,且观察组低于对照组,两组盆腔包块直径均小于治疗前,且观察组小于对照组,差异有统计学意义(P<0.05);治疗后,两组全血低切黏度、血浆黏度和全血高切黏度水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:金丹盆乐汤保留灌肠联合克林霉素治疗CPID患者可改善炎性因子水平,降低血液流变学指标水平和盆腔积液深度,缩小盆腔包块直径,效果优于单纯克林霉素治疗。
Objective:To observe effects of Jindan Penle decoction retention enema combined with Clindamycin in treatment of patients with chronic pelvic inflammatory disease(CPID).Methods:A prospective study was conducted on 72 patients with CPID admitted to the hospital from January 2019 to December 2021.They were divided into control group(35 cases)and observation group(37 cases)according to the random number table method.The control group was treated with Clindamycin,while the observation group was treated with Jindan Penle decoction retention enema on the basis of that of the control group.The levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-2(IL-2)],the pelvic effusion depth,the pelvic mass diameter,the hemorheology index levels(high shear whole blood viscosity,low shear whole blood viscosity,plasma viscosity),and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of TNF-αin the two groups were lower than those before the treatment,and that of observation group was lower than that of the control group;the levels of IL-2 in the two groups were higher than those before the treatment,and that of observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of the depth of pelvic effusion in the two groups were lower than that before the treatment,and that of the observation group was lower than that of the control group;the diameters of pelvic mass in the two groups were smaller than those before the treatment,and that of the observation group was smaller than that of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of whole blood low shear viscosity,plasma viscosity and whole blood high shear viscosity in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Jindan Penle decoction retention enema combined with Clindamycin in the treatment of the CPID patients can improve the levels of inflammatory factors,reduce the levels of hemorheology indexes and the pelvic effusion depth,and reduce the pelvic mass diameter.Moreover,it is superior to single Clindamycin treatment.
作者
洪香桃
李三妹
蔡瑶
刘英
钟佳芮
HONG Xiangtao;LI Sanmei;CAI Yao;LIU Ying;ZHONG Jiarui(Department of Obstetrics and Gynecology of Fengxin County Hospital of Traditional Chinese Medicine,Yichun 330700 Jiangxi,China)
出处
《中国民康医学》
2022年第23期92-95,共4页
Medical Journal of Chinese People’s Health
关键词
金丹盆乐汤
保留灌肠
克林霉素
慢性盆腔炎
炎性因子
血液流变学
不良反应
Jindan Penle decoction
Retention enema
Clindamycin
Chronic pelvic inflammatory disease
Inflammatory factor
Hemorheology
Adverse reaction
