摘要
寻常型银屑病,中医称为“白疕”。现代医学认为银屑病发生、发展与T淋巴细胞异常活化有一定关联。研究表明,银屑病患者体内的辅助性T淋巴细胞(Th)1/Th2平衡向Th1细胞分化优势偏移,以及Th17细胞可以通过IL-23/Th17轴引起并加剧银屑病皮损中的炎症反应。中医治疗寻常型银屑病的研究发现中医汤药、中成药及中医外治如火针疗法、中药药浴等可改善银屑病患者的Th1漂移以及抑制IL-23/Th17轴的作用,从而达到治疗银屑病的目的。故本文综述了中医药治疗寻常型银屑病临床效果及机制研究文献,以期为中医药在诊断治疗寻常型银屑病的临床应用上提供更多地理论及方法学依据,以及为今后寻常型银屑病的治疗提供些许新的思路与方向。
Psoriasis vulgaris is called “Baibi”in traditional Chinese medicine. Modern medicine believes that the occurrence and development of psoriasis is related to the abnormal activation of T lymphocytes. Studies have shown that the helper T lymphocyte(Th)1/Th2 balance in patients with psoriasis is shifted toward the differentiation dominance of Th1 cells,and that Th17 cells can induce and exacerbate inflammatory responses in psoriatic lesions through the IL-23/Th17 axis.Studies on the treatment of psoriasis vulgaris by traditional Chinese medicine have found that traditional Chinese medicine decoction, Chinese patent medicine, and external treatment of traditional Chinese medicine such as fire acupuncture therapy and traditional Chinese medicine medicated bath can effectively improve the Th1 drift in patients with psoriasis and inhibit the IL-23/Th17 axis, so as to achieve the purpose of the treatment of psoriasis. Therefore, this paper reviews the literature on the clinical efficacy and mechanism of traditional Chinese medicine in the treatment of psoriasis vulgaris, in order to provide more geographical and methodological basis for the clinical application of traditional Chinese medicine in the diagnosis and treatment of psoriasis vulgaris, and to provide some new ideas and directions for the treatment of psoriasis vulgaris in the future.
作者
孟娇玉
李领娥
王雅静
刘倩颖
吕子月
MENG Jiaoyu;LI Ling’e;WANG Yajing;LIU Qianying;LYU Ziyue(Graduate School,Hebei University of Traditional Chinese Medicine,Hebei Province,Shijiazhuang050091,China;Department of Dermatology,Shijiazhuang Hospital of Traditional Chinese Medicine,Hebei University of Traditional Chinese Medicine,Hebei Province,Shijiazhuang050051,China;Graduate School,Hebei North University,Hebei Province,Zhangjiakou075000,China)
出处
《中国医药导报》
CAS
2022年第33期37-40,58,共5页
China Medical Herald
基金
国家重点研发计划“中医药现代化”研究专项项目(2018YFC1705301)。
