摘要
目的 探讨利福喷丁辅助抗生素对结核病患者免疫功能的影响。方法 80例结核病患者作为研究对象,根据患者入院的先后顺序将其分为对照组和观察组,每组40例。观察组患者选择利福喷丁辅助左氧氟沙星治疗,对照组患者选择单独左氧氟沙星治疗。比较两组患者的临床转阴率、空洞闭合率,肺部病灶吸收情况, T淋巴细胞亚群水平,不良反应发生情况。结果 观察组患者的临床转阴率90.00%、空洞闭合率82.50%高于对照组的72.50%、62.50%,差异具有统计学意义(P<0.05)。观察组患者的肺部病灶吸收率77.50%高于对照组的57.50%,差异具有统计学意义(P<0.05)。治疗后,两组患者的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且观察组患者的CD3^(+)(50.68±3.22)%、CD4^(+)(52.51±2.18)%、CD4^(+)/CD8^(+)(1.82±0.34)高于照组的(48.23±3.81)%、(50.66±2.54)%、(1.47±0.62),差异具有统计学意义(P<0.05)。两组患者的不良反应发生情况比较,差异无统计学意义(P>0.05)。结论 利福喷丁辅助抗生素对结核病患者的治愈率更高,可有效促进空洞闭合,并且病灶部位的吸收更快,能够有效的改善患者的免疫功能,不会增加患者的不良反应,辅助作用明显。
Objective To discuss the effects of rifapentine adjuvant antibiotics on immune function in patients with tuberculosis. Methods A total of 80 cases of tuberculosis patients were selected as the research subjects, and they were divided into the control group and the observation group according to the order of admission, with 40 cases in each group. Patients in the observation group were treated with rifapentine combined with levofloxacin, and patients in the control group were treated with levofloxacin alone. The clinical negativeconversion rate, cavity closure rate, absorption of lung lesions, T lymphocyte subset levels, and occurrence of adverse reactions were compared between the two groups. Results The clinical negative-conversion rate and cavity closure rate of the observation group were 90.00% and 82.50%, which were higher than 72.50% and 62.50% of the control group, and the differences were all statistically significant(P<0.05). The absorption rate of lung lesions 77.50% in the observation group was higher than 57.50% in the control group, and the difference was statistically significant(P<0.05). After treatment, the levels of CD3, CD4, CD4/CD8in the two groups were higher than those before treatment in this group;the CD3(50.68±3.22)%, CD4(52.51±2.18)%, CD4/CD8(1.82±0.34) in the observation group were higher than(48.23±3.81)%,(50.66±2.54)%,(1.47±0.62) in the control group;the differences were all statistically significant(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Rifapentine adjuvant antibiotics have a higher cure rate for tuberculosis patients, and can effectively promote cavity closure,and absorb faster at the lesion site, effectively improve the patient’s immune function without increasing the patient’s adverse reactions, and have a significant adjuvant effect.
作者
冯霭媚
FENG Ai-mei(Jinshazhou Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510000,China)
出处
《中国实用医药》
2022年第25期23-26,共4页
China Practical Medicine
