摘要
目的:探讨同型半胱氨酸(Hcy)与肝豆状核变性[又称Wilson病(WD)]患者中医证型的相关性。方法:收集符合纳入标准的WD患者356例作为WD组,同时纳入100例正常人作为健康对照,所有入选的对象均行血清Hcy水平测定及性别、年龄分析。此外,所有WD组患者均采用总体评定量表(GAS)与Barthel指数(BI)评定量表进行评定,并分析GAS评分及BI评分与WD组患者血清Hcy水平之间的相关性。结果:WD组患者血清Hcy水平显著高于对照组,差异具有统计学意义(P<0.01)。不同证型之间差异明显,组间比较差异具有统计学意义(P<0.05,P<0.01),其证候顺位依次为湿热内蕴组、痰瘀互结组、肝肾阴亏组。相关性分析发现WD患者血清Hcy水平与GAS评分呈正相关(P<0.01),与BI评分呈负相关(P<0.01)。差异性分析显示WD组的性别之间差异具有统计学意义,男性的总体血清Hcy水平显著高于女性(P<0.01);而年龄差异无统计学意义。结论:血清Hcy水平与WD关系密切,在WD不同中医证型间有显著差别,其水平变化可一定程度上反映不同中医证候和临床病情情况。因此,检测Hcy水平可作为辨别WD中医证型类型、评估病情及预后的参考。
Objective:To investigate the correlation between homocysteine(Hcy)and traditional Chinese medicine(TCM)syndromes in patients with hepatolenticular degeneration[also known as Wilson’s disease(WD)].Method:A total of 356 patients with WD who met the inclusion criteria were enrolled and assigned to the WD group,while 100 healthy people were included as healthy controls.All participants underwent serum Hcy level measurement and the analysis of gender and age.Furthermore,all patients in the WD group were assessed by global assessment scale(GAS)and Barthel scale/index(BI).The correlation between GAS and BI scores and the serum Hcy levels of patients in the WD group was analyzed.Result:The serum Hcy levels in the WD group were significantly higher than those in the healthy control group,(P<0.01).The differences between different types of TCM syndromes were significant(P<0.05,P<0.01),which were ranked as follows:Dampness-heat internal accumulation syndrome,phlegm-stasis combination syndrome,and Yin deficiency in liver and kidney syndrome.The correlation analysis revealed that serum Hcy levels in WD patients were positively correlated with GAS scores(P<0.01),while negatively correlated with BI scores(P<0.01).The analysis of variance indicated remarkable gender difference in the WD group(P<0.01),with higher overall serum Hcy levels in men than in women,while there were no marked differences in the results between age and serum Hcy levels.Conclusion:The serum Hcy level closely correlates with WD,showing significant differences among different TCM syndromes of WD,and the level changes can reflect different TCM syndromes and clinical conditions.Therefore,the detection of Hcy level can be used as a reference to identify the type of TCM syndrome of WD and assess the condition and the prognosis.
作者
丁宇峰
张静
杨文明
郝文杰
DING Yufeng;ZHANG Jing;YANG Wenming;HAO Wenjie(Anhui University of Chinese Medicine,Hefei 230038,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China;Key Laboratory of Xin'an Medicine,Ministry of Education,Hefei 230038,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第23期110-116,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81973825)
国家中医药管理局中医药循证能力建设项目(2019XZZX-NB001)
安徽省高校协同创新项目(GXXT-2020-025)。
关键词
肝豆状核变性
WILSON病
同型半胱氨酸
中医证型
相关性
hepatolenticular degeneration
Wilson’s disease
homocysteine
traditional Chinese medicine(TCM)syndrome
correlation
