摘要
目的 探讨盐酸氨溴索联合盐酸丙卡特罗治疗小儿肺炎支原体肺炎的临床效果及对患儿免疫功能和炎症细胞因子水平的影响。方法 选取2019年1月-2021年12月在南昌市第三医院接受治疗的小儿肺炎支原体肺炎患儿84例为研究对象,随机分为对照组和观察组,每组各42例,对照组患儿给予常规治疗,观察组患儿给予盐酸氨溴索联合盐酸丙卡特罗治疗。对比两组患儿临床治疗效果、T淋巴细胞亚群水平、血清炎症细胞因子水平及临床症状消失时间等指标。结果 观察组患儿临床治疗总有效率(92.9%)显著高于对照组(81.0%),差异有统计学意义(χ^(2)=7.156,P<0.05)。治疗前,两组患儿T淋巴细胞亚群和炎症细胞因子水平比较,差异均无统计学意义(均P>0.05)。治疗后,观察组患儿CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)及IL-4水平均显著高于对照组[(69.54±2.74)%vs.(60.32±2.31)%,(41.36±2.95)%vs.(37.52±2.63)%,(1.52±0.32)vs.(1.04±0.12),(5.41±0.58)ng/ml vs.(3.96±0.65)ng/ml],差异均有统计学意义(t=16.673、6.297、9.102及10.787,均P<0.05),CD8^(+)、TNF-α、IFN-γ及IL-2水平显著低于对照组[(27.24±1.62)%vs.(36.54±2.18)%,(4.16±2.57)ng/ml vs.(7.52±4.03)ng/ml,(15.24±2.11)ng/ml vs.(18.14±2.65)ng/ml,(177.58±42.51)ng/ml vs.(242.36±45.12)ng/ml],差异均有统计学意义(t=22.191、4.556、5.548及6.772,均P<0.05)。观察组患儿肺部啰音、咳嗽、发热及气喘等临床症状消失时间[(6.62±1.23)d、(4.13±1.44)d、(2.11±1.16)d及(3.64±1.34)d]均短于对照组[(9.88±1.12)d、(6.15±1.53)d、(3.72±1.47)d及(5.56±1.52)d],差异均有统计学意义(t=12.700、6.231、5.572及6.141,均P<0.05)。结论 应用盐酸氨溴索联合盐酸丙卡特罗治疗小儿肺炎支原体肺炎,临床效果显著,可改善患儿T淋巴细胞亚群和炎症细胞因子水平,缩短治疗时间,促进临床康复,治疗效果理想,值得应用。
Objective To explore the curative effect of ambroxol hydrochloride plus procarterol hydrochloride in children with mycoplasma pneumoniae pneumonia and its effect on immune function and inflammatory cytokine levels.Methods A total of 84 children with Mycoplasma pneumoniae pneumonia treated in the Third Hospital of Nanchang from January 2019 to December 2021 were selected as the research objects. The children were randomly divided into the control group and the study group(42 cases in each group). The control group was given routine treatment, while the study group was given ambroxol hydrochloride and procarterol hydrochloride treatment. The clinical treatment effect, Tlymphocyte subsets cytokine levels, serum inflammatory cytokine levels and clinical symptom disappearance time were compared between the two groups.Results The total effective rate in the study group(92.9%)was obviously higher than that in the control group(81.0%), the difference was statistically significant(χ^(2)=7.156, P<0.05);there was no comparable difference in the levels of T lymphocyte subsets cytokines and inflammatory factors between the two groups before treatment(P>0.05).After treatment, the serum levels of CD3^(+), CD4^(+), CD4^(+)/CD8^(+)and IL-4 in the study group were obviously higher compared to control group[(69.54±2.74)% vs.(60.32±2.31)%,(41.36±2.95)% vs.(37.52±2.63)%,(1.52±0.32)vs.(1.04±0.12),(5.41±0.58)ng/ml vs.(3.96±0.65)ng/ml],the differences were statistically significant(t=16.673,6.297,9.102 and 10.787, all P<0.05)and the levels of TNF-α、IFN-γ、IL-2 were lower compared to control group[(4.16±2.57)ng/ml vs.(7.52±4.03)ng/ml,(15.24±2.11)ng/ml vs.(18.14±2.65)ng/ml,(177.58±42.51)ng/ml vs.(242.36±45.12)ng/ml],the differences were statistically significant(t=22.191,4.556,5.548 and 6.772, all P<0.05).The time to disappearance of clinical symptoms such as pulmonary rales, cough, fever and asthma in observation group[(6.62±1.23)d,(4.13±1.44)d,(2.11±1.16)d,(3.4±1.34)d] were markedly lower than those in control group[(9.88±1.12)d,(6.15±1.53)d,(3.72±1.47)d,(5.56±1.52)d],the differences were statistically significant(t=12.700,6.231,5.572 and 6.141,all P<0.05).Conclusion The application of ambroxol hydrochloride and procarterol hydrochloride in the treatment of mycoplasma pneumoniaepneumonia in children has a significant clinical effect, which can improve the level of T lymphocyte subsets cytokines and inflammatory factors, shorten the treatment time, promote clinical rehabilitation, and the treatment effect is ideal and worthy of application.
作者
李清祥
熊文祺
蒋沁炆
胡犁丽
LI Qing-Xiang;XIONG Wen-Qi;JIANG Qin-Wen(Department of Laboratory Medicine,the Third Hospital of Nanchang,Nanchang,Jiangxi 330009,China)
出处
《中国妇幼保健》
CAS
2022年第21期3936-3939,共4页
Maternal and Child Health Care of China
基金
江西省卫生健康委科技计划项目(20204062)。
关键词
盐酸氨溴索
盐酸丙卡特罗
小儿肺炎支原体肺炎
T淋巴细胞
炎症细胞因子
Ambroxol hydrochloride
Procarterol hydrochloride
Mycoplasma pneumoniae pneumonia in children
T lymphocyte subsets cytokines
Inflammatory cytokines
