摘要
脓毒症是由感染引起的全身炎症反应综合征,其核心机制是免疫功能紊乱。巨噬细胞具有极化、自噬、调节炎症反应和杀灭微生物的作用,是参与机体非特异性免疫的重要组成部分。研究发现,巨噬细胞可以通过极化、自噬等生物学行为在脓毒症的免疫调节中发挥重要作用。文章就巨噬细胞极化、自噬在脓毒症发病机制领域相关研究进展进行综述。调控巨噬细胞生物学行为有望成为未来脓毒症治疗的新靶点。
Sepsis is a systemic inflammatory syndrome caused by infection,with the core mechanism of immune dysfunction.Macrophages are involved in autophagy,phagocytosis,regulation of inflammatory response and killing microorganisms,and are an important element of non-specific immunity to the body.It has been found that macrophages play an important role in the immune regulation of sepsis through biological behaviors such as polarization and autophagy.The current paper summarized the research progress on macrophage polarization and autophagy in the pathogenesis of sepsis.Regulating macrophage biological behavior is expected to be a new target for the treatment of sepsis in the future.
作者
周璐璐
王雅菲
陈君
谢克亮
Zhou Lulu;Wang Yafei;Chen Jun;Xie Keliang(Department of Anesthesiology,Tianjin Huanhu Hospital,Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration,Tianjin 300350,China;Tianjin Medical University,School of Basic Medical Sciences,Tianjin 300070,China;Department of Anesthesiology,General Hospital of Tianjin Medical University,Tianjin Research Institute of Anesthesiology,Tianjin 300052,China;Department of Critical Care Medicine,General Hospital of Tianjin Medical University,Tianjin 300052,China;Translational Research Institute of Intensive Care Medicine,College of Anesthesiology,Weifang Medical University,Weifang 261053,China)
出处
《国际麻醉学与复苏杂志》
CAS
2022年第9期984-987,共4页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81971879,81772043)
天津市自然科学基金(17JCYBJC24800)
天津市科技计划项目重点研发计划科技支撑重点项目(18YFZCSY00560)。
关键词
脓毒症
巨噬细胞
自噬
极化
发病机制
Sepsis
Macrophages
Autophagy
Polarization
Pathogenesis
